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If your clients have such markers, they probably have something else going in addition to, or instead of ME/CFS. In over 30 years of research, with over 50+ studies on cortisol patterns or related neuroendocrine systems, researchers have only found equivocal results. This should be a clue...

Even those with lung scarring will only suffer pulmonary related symptoms, not ME in general. Such pulmonary issues can reduce exercise capacity, but don't actually cause fatigue or other ME symptoms beyond that.

It is possible, but not with low-efficacy vaccines (60-70% efficacy) and will unfortunately require adapting bi-valent vaccines to target circulating variants. And children will need to be vaccinated too. But I agree with the overall narrative - vaccines alone aren't a solution. Elimination...

Sure, but if there are problems due to a dietary deficiency then it will show up anyway, which leads us back to the need for extracellular physiological mechanisms for the problem to show up post-exercise. I'm not seeing evidence of a physiological feedback loop. Yes, there is a problem with...

I apologise for your premature excitement, I was referring to signs in clinical practise rather than a formal study, though I agree it would be interesting to see a high-quality study of liver fibrosis (especially as part of a community/population-based study).

Fatigue is a common and non-specific symptom, with many causes. Solutions that may work for some patients suffering from fatigue may not be generalisable to ME/CFS, which is why strict clinical criteria is necessary. The lack of formal diagnoses make your anecdotes less compelling. Likewise, we...

@Hilda Bastian's latest vaccine evidence summary (warning: it's long!) https://absolutelymaybe.plos.org/2021/03/16/community-impact-data-3-new-covid-vaccines-and-trials-in-children-a-month-of-dilemmas-and-good-news/

The most likely reason is that patients have a great deal of unmet human needs and this is the only available outlet for seeking help for those needs.

If only it was a "race". All I'm seeing is researchers running round in circles at the start line.

I had that impression too. Much of the ideas remind me of certain discussions on PhoenixRising and there is the curious mention of CD36 without explanation too (something I discussed).

Us chemists prefer using gallium spoons rather than mind-tricks.

Yes, small changes like this in uncontrolled studies is usually just response bias. It certainly provides much lower protection from the South African variant. But I think lunarainbows was talking about in the years to come, when further new variants emerge, which vaccine-escape is more likely.

Exactly! I also became ill at 15 and had a powerful belief I would get better - a belief that took almost a decade to diminish!

Alternative conclusion: the Maslach Burnout Scale lacks specificity when used by longcovid patients.

How exactly are these anti-PDC antibodies getting into the mitochondria? The manuscript reads as if they plucked together a few ideas and are trying really hard to make them all fit together, with scattered fragments of biochemistry mechanisms. The pathway diagrams are interesting, but they...

ME/CFS and biased attention https://davidfmarks.com/2021/03/13/me-cfs-and-biased-attention/

VO2Max on a ramped cardiopulmonary test indicates the maximum amount of oxygen that is delivered to the muscles. In most people, this is limited by the strength of the heart, the blood volume and the architecture of the microvascular system in the vicinity of the muscles. In highly trained...

The very same claim can be made about non-pharmacological 'rehabilitation' approaches.

Those steps are part of normal immune functioning. The trouble only starts if somehow the virus manages to evade the normal processing of the internalised receptor complex. They are suggesting persistent infection of those cells. But there can be epigenetic changes that can persist in that...

Even if you are well, but merely deconditioned, that recommendation is far from ideal from an exercise physiology perspective. More time at a constant intensity (rather than shorter amounts of exercise at varying levels of intensity) and more times per week isn't necessarily better, especially...