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This may seem surprising, but highly sensitive and specific blood based biomarkers are rare. Many diseases do not have them. Most blood tests are quite superficial and test very little of what goes on in the body. The first is that there are tens of thousands of things to test, the second is...

I disagree. Much of his COVID-19 reporting for example has been of typical journalistic quality - eg talking about the week's hot topic and lacking a true scientific perspective. There is plenty to criticise. He was saying severe COVID-19 cases were due to a cytokine storm, despite the...

That's the mystery isn't it? The hypothesis needs to be quite specific and tick a lot of boxes (including many things that have been ruled out).

HPA axis hypotheses have almost been done to death. The main problem is that basal serum cortisol (or the other markers discussed) is neither a sensitive, nor specific predictor of ME/CFS or symptoms. Yes there is attenuated morning salivary Cortisol concentrations in some patients but this is...

Of course! Lived experience of other people only matters when it agrees with our preconceived ideas and is always wrong when it conflicts with such ideas! ;)

The EU approved it, I think Germany is still going to avoid it's use for over 65s. The tweet shows the lack of data (1 covid case each in both vaccine and placebo groups)

This is my confirmation bias talking, but I am very excited about this study. I have been trying to explain links as to why certain neurological syndromes (GBS for example) often lead to long term CFS-like symptoms, despite apparent neurological recovery. This is why I've been interested in...

Moved post Why Germany did not approve the use of AstraZeneca vaccine for over 65s: Novavax interim data is good (especially given Australia's vaccine supply issues...), but worse South African variant data is a little concerning:

I mentioned this study several times: https://academic.oup.com/bmb/article/69/1/197/523356 I guess that was enough to get on the list.

Nothing wrong with liking your own posts! :laugh:

I'm just glad we managed to coax a speculative hypothesis out of you!

I think it is important not to confuse cause and effect. If there is increased afferent signalling, why wouldn't we expect increased salience network activity? This may be necessary to maintain increased concentration during a cognitive task and it is that increased effort that is often...

This is the study itself: Notions of “optimal” posture are loaded with meaning. Perceptions of sitting posture among asymptomatic members of the community https://www.sciencedirect.com/science/article/abs/pii/S2468781220306159?dgcid=coauthor A prior review from 2007 by one of the authors...

Is this exclusive to SARS-CoV-2, or a general phenomenon of CD8+ T-cells during prolonged infections?

We've known about her views for a long time. ‘Health for me’: a sociocultural analysis of healthism in the middle classes (2004) Trisha Greenhalgh, Simon Wessely https://academic.oup.com/bmb/article/69/1/197/523356 (the article tries to suggest that "articulate, health-aware and...

It's the percentage of people who were initially infected (whom were included in the survey).

I think this is as much about who is vaccinated (eg at risk people), and the short followup periods (the clinical trials had 2-3 months followup time). Still, I agree it means the delayed dosage strategy is flawed and we should not be complacent about the vaccine itself protecting...

Every other vaccine has been tested on the basis of reducing symptoms, rather than reducing transmission. It just so happens that they're effective at doing the latter too. None of the phase 3 vaccine trials are sufficiently powered to get a true idea about transmission rates - they'd need ten...

Most of the discussion on twitter are people saying, 'I don't feel any better' or 'I felt a bit better for a few days and then crashed' As far as anecdotal observations go, it's not terribly compelling when few people have the same experience.

Through exploiting the guilt of a government who failed to protect (or warn) it's citizens? Through big numbers of sufferers in a short period of time?