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It's not any single thing that I'm looking for, but a list and hopefully we might spot some clear patterns.

Part 2: Integrins are also common viral entry points (including herpesviruses and picornaviruses, Q fever, Ross River virus etc). SARS‐COV‐2 and infectivity: Possible increase in infectivity associated to integrin motif expression https://onlinelibrary.wiley.com/doi/10.1002/jmv.25831 A...

I'd like to propose a thought experiment for all you s4me people, starting with what do EBV and SARS-2 (or SARS-1) have in common in terms of infecting cells and causing disease?

Neuropilin-1 is a host factor for SARS-CoV-2 infection James L. Daly, Boris Simonetti, Carlos Antón-Plágaro, Maia Kavanagh Williamson, Deborah K. Shoemark, Lorena Simón-Gracia, Katja Klein, Michael Bauer, Reka Hollandi, Urs F. Greber, Peter Horvath, Richard B. Sessions, Ari Helenius, Julian A...

Yes, much of this is known already and doesn't confirm the presence of a certain hypothesised metabolic trap.

The acute responses to exercise were interesting, but I'm sure we would have appreciated longer testing, namely 24 and 48 hours!

Wow, it'd help if they isolated it down to one of those extracts. It's impossible to say what would be the relevant bioactive compound from that long list!

(I apologise if this seems to be a little obscure). Animal models suggest a relationship between dystrophin and muscle fibre fatiguability. Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications...

Optimal "fat utilisation" only matters if your goal of exercise is to lose fat! If you want to increase strength or fitness, unfortunately the only way to do so is through intense activity. But keep in mind this intensity can be extremely brief - it is about quality, not quantity.

Notably, they did publish the actual questions in the manuscript, but they're the usual nonsense. Each question has a short blurb to guide the scorer on severity. Note the bit "Disregard any statement about the cause being organic." mhmm. Also, I've never heard the words "micturition" or...

From: https://corteneinc.com/development/ 1. is pure speculation as no direct measure of CRF2 expression or function was used. 2. is probably justified, but none of the other claims are justified as there was no comparison group. 3. Claims about efficacy are not justified from the data, due to...

Since is study is medical record based, much of these findings reflect physician-biased patterns of diagnosis, rather than the symptoms themselves. The study could have been used to estimate incidence of diagnosis (vs age) and diagnosed prevalence for the primary conditions, but they chose...

It's funny how they never ask the patients as to whether they find the questions to be understandable/relevant/useful. They've had 18 years to do it too.

Patients who have various symptoms associated with illness tend to have an increase baseline in their effort reporting associated with these symptoms, but the rate of increase in effort during aerobic activity is normal (given the level cortical output), when normalised to that increased baseline.

1&2 Day CPET studies have shown substantial overlap (on the 1st day) between patients and controls, with some patients having above average cardiovascular fitness (VO2Peak - so the heart/lungs are not deconditioned) for their age/sex, which suggests that for many patients, deconditioning cannot...

Indeed. After reading this paper, my conclusion is less research on cortisol in FMS and CFS is needed. I don't find any of these results particularly interesting.

Yep, they aren't going to be treated any more seriously than us. Just more poor souls joining the fray.

Mhmm.

Only patients with significantly above average cognitive ability are usually willing to participate in studies like this in the first place. The study didn't prospectively study these participants from before they became ill, hence the study is only of "suggestive" quality evidence.

The sad part is I have had a few friends with Schizophrenia and I had asked them about the controversy between Coyne/Laws and Bentall on CBT for psychosis and they were both of the opinion that CBT was useless and the outcome measures used by Bentall and others were not useful...