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I'd also argue that evidence of central fatigue is also strong for CFS, though the underlying cause of that central fatigue is debated (and sadly, often debated by people who understand very little of the physiology) The consistent finding is reduced workload (usually measured in watts) at the...

The former. Deconditioning simply means lower performance at a given heart rate. I don't think it is deconditioning. Having ME/CFS means it is more difficult to exercise if you are not used to it, and it will feel like your legs can't work any harder. Some people may think that this is their...

Either that, or your body is broken!

VO2Peak can still increase while RER plateaus by increasing ventilation and delivery of that oxygen to the muscle (eg by achieving a higher heart rate or higher blood pressure). But more to the point, how many participants didn't achieve an RER of 1.1? We don't know. Note that the ICF cases...

Or there is a true effect. Another study by this clinic provides more detail on the diagnostic process: https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02397-7.pdf Unfortunately this level of detail was not stated for the current CPET studies. Though it's quite...

It's more than just the last week or two that is important to consider. Notably, in Mongolia, they're now trying to secure supply of the Pfizer vaccine to be offered as boosters...

No. I think it is due having double the number of participants and is more reflective of real-world variability during the test (also given that I don't believe all participants worked hard enough to achieve a true VO2 Max).

I'd rather demonstrate the difference with electromyography, MR spectroscopy, doppler flowmetery (and even pharmacological nerve blockade), rather than a nightmarish scenario of daily maximal CPETs! Even if the CPETs are not maximal, it is still a strong ask of patients.

Same, it is only a problem when suffering from PEM and I find it hard to concentrate.

I still sweat and shiver. ¯\_(ツ)_/¯

I'm not convinced this is a great success given COVID case numbers are high and increasing in countries that have mostly relied on the BBIBP-CorV vaccine (Such as Mongolia and Bahrain), despite almost 60% of the population being vaccinated.

Anyone spot the error? ICF BMI : 224.2 (kg/m2) Not sure the participants are even human with that number! For what purpose though? It will still be unsuitable as a diagnostic marker due to the burden placed on patients. I'm trying to put this politely, but a the reason why a few patients...

While the analysis was retrospective, I don't think this had anything to do with the actual diagnoses, which was prospective (as referred to the clinic). They certainly didn't change the diagnosis on the basis of the CPET, which would be circular! Yeah, nah!

There is no established link.

India could make more than enough doses, not only for themselves but for other countries - if not for the fact that the corporations who own the intellectual property have decided to maximise profit and only grant exclusive licenses (Serum Institute of India) nor not grant licenses at all...

Wow, I don't understand how someone could get it so wrong?

The female data shows a similar pattern, however there was some overlap between patients and controls - several ICF patients had a small (smaller than CFS patients) drop in peak workrate and workrate at the ventilatory threshold.

Keep in mind the authors made many statistical comparisons and did not attempt to correct for multiple comparisons (despite having a reasonable n=160 sample size) some of the metabolite levels were associated with nicotine use, but this was not reported in the abstract at all. None of the...

Figure 4 (not shown by Sly saint in above post at time of posting) is very curious - 100% of the idiopathic cases either reproduced or increased their workload at the ventilatory threshold, whereas most patients had a decline. However absolute difference was not large, so this is not going to be...

The evidence for that is rather weak, serological tests like those used in the cited study lack the requisite specificity.