Search results

HAVCR2 (TIM-3) on Wikipedia The page also lists some ligands that bind to TIM-3, a couple of which rang a bell. It lists CEACAM1. We've seen upregulation of CEACAM3, though I'm not sure how related they are. Edit: CEACAM1 was upregulated in long COVID but not ME/CFS in the quoted...

Now published: post with link here ******* Identification of soluble biomarkers that associate with distinct manifestations of long COVID Marcus Buggert, Yu Gao, Curtis Cai, Sarah Adamo, Elsa Biteus, Habiba Kamal, Lena Dager, Kelly Miners, Sian Llewellyn-Lacey, Kristin Ladell, Pragati...

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome Angela P Presson, Eric M Sobel, Jeanette C Papp, Charlyn J Suarez, Toni Whistler, Mangalathu S Rajeevan, Suzanne D Vernon, Steve Horvath Background: Systems biologic approaches such as...

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome Benjamin N Goertzel , Cassio Pennachin, Lucio de Souza Coelho, Brian Gurbaxani, Elizabeth M Maloney, James F Jones Objective: This paper asks whether the presence...

I'll make a list of anecdotal reports of rapamycin use in ME/CFS or long COVID. I'm sure if I kept going through Reddit search results for "rapamycin" I'd find more, but I'm tired now. Worsened Phoenix Rising Phoenix Rising (temporary symptoms after stopping: Phoenix Rising) Phoenix Rising No...

Old video of Ron Davis, mentions mTOR inhibitors. (Starts at 5:05) I don't see why a mutation in mTOR implies that inhibiting it will make you worse. Is his thinking that a mutation is probably making it work less effectively, so inhibiting it would be adding to the problem? Isn't it...

I read about this study recently, might be relevant. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children, 2016, Stein et al

Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features Maddalena Ruggieri, Giulia Paparella, Livio Clemente, Giuseppe Libro, Concetta Domenica Gargano, Marina de Tommaso Background Plasma neurofilament light chain...

My guess is it might be the opposite. The body is okay with using maximum energy at night for healing, and this leads to feeling like crud for some reason, but during the day, when you need to be alert for activities, the healing gets toned down and energy gets rerouted to activities of being...

Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome Akifumi Kishi, Zbigniew R. Struzik, Benjamin H. Natelson, Fumiharu Togo, Yoshiharu Yamamoto Abstract Physiological and/or pathological implications of the dynamics of sleep stage transitions have...

Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review Melinda L Jackson, Dorothy Bruck Abstract Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a chronic, disabling illness that affects approximately 0.2% of the population. Non-restorative sleep...

They did include a lot of covariates, including diet: And they don't say they found a causal link, but suggest it's a possibility.

Study completion has been changed from 2025 to 2028. ClinicalTrials.gov

Paper on the immunotherapy (thread): Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration, 2018, Ryu et al

OMF released a Youtube video that is an interview with David Systrom about the study.

I contacted one of the authors, William Stringer, to ask about workload at AT, and he very kindly provided the data for that timepoint and allowed me to share it here. The mean did decrease, but just by a little bit. First column is day 1, second column is day 2. Here's a plot I made of...

The trial registration was updated a few days ago: The enrollment has increased from 100 to 150 People with long COVID are now eligible to participate as well. Primary outcomes have been expanded from just SF-36 to also include MFI and Bell scale. ClinicalTrials.gov Edit: This is interesting...

What do you think of liver-related, as mariovitali was saying:

Notable lab findings n= 19 PCS/ME/CFS and 23 PCS/non-ME/CFS (Some participants were not tested for some of the following markers.) Hand grip strength (HGS) correlations with lab markers