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Yes, I was wondering why I'm seeing so many papers talking about bed rest in TB, but almost none in other infections.

Another two that found no benefit from bed rest in tuberculosis: Is cavity closure in pulmonary tuberculosis influenced by bed-rest?, 1960, Wynn-Williams et al I can't access this one, but the article below it describes the results: Late Results of Modified Bed Rest in Active Uncomplicated...

Surprisingly, I found an RCT of bed rest for tuberculosis. Also an old paper. Bed rest in the treatment of pulmonary tuberculosis, 1956, Tyrrell et al They admitted every other patient who presented with TB to a hospital for 3 to 6 months bed rest, and instructed the rest to continue normal...

Seems this was the topic of his talk at a Renegade Research talk yesterday.

Guardian angels off duty? ME/CFS is Sustained by an Impaired Stress Response in the Central Nervous System Herbert Renz-Polster Abstract ME/CFS researchers agree that ME/CFS is a multisystem disease with a multitude of pathobiological features including endothelial dysfunction, immune...

What exactly makes it distinguishable? Just the fever or something more?

Data that would be useful for this would be how bed rest affects the duration/severity of a sickness. That's the commonly prescribed advice from our doctors and parents. "Rest so that the body can heal." If this advice is based on a real effect, I think that's basically evidence of PEM: if you...

I thought it might be worthwhile to have a discussion comparing and contrasting the symptoms of an acute infection (a week or two of flu, cold, staph, etc.) and ME/CFS. Viral persistence is often mentioned in discussions of mechanism theories. I personally think there's a good chance ME/CFS is...

Maybe I don't feel "poisoned" because I never experience nausea with ME/CFS? Edit: Does anyone feel "poisoned" but never experience nausea as a symptom of ME/CFS?

I hear "poisoned" so often, but I don't have a good idea of what that really means. "Malaise" feels like it fits me fine. I don't know what it feels like to be poisoned. Is it a similar feeling to food poisoning? Alcohol poisoning?

Interestingly, only one condition was significantly more common in off-label rapamycin users than non-users: canker sores. It says things like depression and anxiety were less common, but I don't think any causality can be inferred.

Evaluation of off-label rapamycin use to promote healthspan in 333 adults Tammi L Kaeberlein, Alan S Green, George Haddad, Johnny Hudson, Anar Isman, Andy Nyquist, Bradley S Rosen, Yousin Suh, Sajad Zalzala, Xingyu Zhang, Mikhail V Blagosklonny, Jonathan Y An, Matt Kaeberlein Abstract...

mTOR inhibition improves immune function in the elderly Joan B. Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, Baisong Huang, Michael A. Lonetto, Holden T. Maecker, John Kovarik, Simon Carson, David J. Glass, Lloyd B. Klickstein Abstract Inhibition of...

Some info on the immunostimulatory properties of rapamycin. Sirolimus (rapamycin) on Wikipedia: It cites the following paper (which is from a different year than Wikipedia says, not sure why). I added line breaks for easier reading. Regulation of innate immune cell function by mTOR, 2018...

I wonder why. They tested just about everything else, including work at another timepoint. And decrease in work at AT is one of the most consistent findings in ME/CFS, so it seems strange to not include that.

Oh, and then the separate Simmaron trial gives a different reason:

From their blog linked by wigglethemouse, they cite a few things:

I decided I'm going to try to do a variation of this idea. The plan is to make a wiki (using the same software as Wikipedia/MEpedia) about the research of chronic illnesses (including ME/CFS, multiple sclerosis, depression, cancer, etc). It won't just be a normal encyclopedia format like...

Someone on Reddit in the ME/CFS trial said Simmaron just finished the study. Their doctor told them most of her patients didn't benefit from it. This person had pretty minor improvements in brain fog and fatigue. They didn't say if they know which group (evidence of authophagy disruption or not)...