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  1. Jonathan Edwards

    BMJ: Chronic fatigue syndrome and Long Covid, moving beyond the controversy, 2021, Newman

    That's so. But to validate the concept of individualisation it is pretty neat.
  2. Jonathan Edwards

    BMJ: Chronic fatigue syndrome and Long Covid, moving beyond the controversy, 2021, Newman

    Yes, it is intriguing @Esther12. I have been having a discussion on HealthWatch (where a lot of people have worked to dislodge homeopathy from the NHS). Just this morning it came to me that the comment (source confidential but maybe now found in any BACME type mag), that it didn't really matter...
  3. Jonathan Edwards

    Tests for borrelia (Lyme)

    But this would be indirect - detecting supposedly specific phage DNA patterns. And all you need is some leeway in the primers and overcooking and you have false positives, if my experience is anything to go by. I agree with Milo that a link up with Red Labs is not encouraging.
  4. Jonathan Edwards

    A general thread on the PACE trial!

    Why do the same names and the same organisations keep reappearing in this story and in such paradoxical ways? (A rhetorical question.)
  5. Jonathan Edwards

    Long covid—mechanisms, risk factors, and management, 2021, Crook et al

    This reads like a student essay assignment. (In fact the assignment is likely to have been given to the senior author who passed it down to a fresh junior wanting publications.) It is devoid of any intelligent analysis and nobody has proof read the English properly. Complete drivel again I am...
  6. Jonathan Edwards

    A general thread on the PACE trial!

    I find Dr McFarlane's approach a bit scattershot and he obviously has his own agenda but I was having a conversation with Nick Ross on another forum couple of days ago and I find the connections suggested in this blog interesting!
  7. Jonathan Edwards

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    Floaters can be seen on standard slit lamp examination. I have had them for decades according to my ophthalmologists and opticians.
  8. Jonathan Edwards

    A general thread on the PACE trial!

    I find this strangely arm's-length sentence intriguing: This was a classic demonstration of the importance of transparency: critics of the study (of whom there are many) had to make a Freedom of Information request and wait years to see the data — at which point they argued that their...
  9. Jonathan Edwards

    USA: InCellDx Dr Patterson - New lab service offering cytokine tests to Covid longhaulers

    There is never any room for 'benefit of the doubt' in science. So much work in science is flawed by poor methodology and over enthusiasm. Unless you assume that work may be hyped before you read you will find yourself taken in by all sorts of empty stuff. But generally it is not too difficult...
  10. Jonathan Edwards

    Fibromyalgia Detection Based on EEG Connectivity Patterns, 2021, Martin-Brufau et al

    So where are the data please, mate? I think you have to be a bit thick to write that sentence.
  11. Jonathan Edwards

    USA: InCellDx Dr Patterson - New lab service offering cytokine tests to Covid longhaulers

    It will only ramp up if people give it attention - so why give it exposure?
  12. Jonathan Edwards

    Interventions that manipulate how patients report symptoms as a separate form of bias

    The Benedetti article is interesting in that it is clear that Benedetti himself would like to make use of placebos. One might say that he can hardly complain if the quacks want to as well! I think the parallel with the BPS people, who also feel that it is OK for them to make use of the placebo...
  13. Jonathan Edwards

    USA: InCellDx Dr Patterson - New lab service offering cytokine tests to Covid longhaulers

    I cannot see any point in following empty marketing like this. When there is some science I will take a look.
  14. Jonathan Edwards

    Intramuscular Pressure is Almost Three Times Higher in Fibromyalgia Patients..., 2020, Katz et al

    @Hutan, It would take a few thousand words to fully explain the problem here. But in simple terms human tissues are solids. Hydrostatic pressures are properties of liquids. If you try to ascribe hydrostatic pressures to solids you have to be very very careful and know exactly what you are doing...
  15. Jonathan Edwards

    How pandemics strengthen links between viruses and autoimmunity

    The quoted abstract illustrates well how poorly immunologists understand their own terminology (and also the pathology of synovium, which at one time was my special expertise). A dysregulated inflammatory response is not' autoimmune' unless there is actual immune reactivity to self, as there is...
  16. Jonathan Edwards

    How pandemics strengthen links between viruses and autoimmunity

    Read my paper with Jo Cambridge in Immunology 1999! B cells operate on a basis of random generation of antibody types with a chain reaction positive feedback loop for mass production when needed. To explain autoimmunity you need to find a way to trick the chain reaction into activating for self...
  17. Jonathan Edwards

    How pandemics strengthen links between viruses and autoimmunity

    I had not actually read the article but it is the tired old old story I was familiar with from my student days which my 1999 article in Immunology with Jo Cambridge should have finally put to bed. There is not a scrap of evidence for it. Rather than being at the cutting edge of immunology people...
  18. Jonathan Edwards

    How pandemics strengthen links between viruses and autoimmunity

    Let me try a slightly different abstract. Introduction: Viruses might be linked to autoimmunity. Methods: So we allowed at least 193,668,196 people (so far) to get infected with a virus and waited to see if there was a flush of autoimmune disease. Results: none seemed to turn up. Conclusion...
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