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Naviaux wins mitochondria research award. https://bos.etapestry.com/prod/viewEmailAsPage.do?erRef=773.0.734158614&databaseId=OMF&mailingId=44995522&jobRef=773.0.1792966735&key=7ed94938c43c962c1798fe42075987&personaRef=773.0.734158755&memberId=1482001482

This is complicated.

Ummm clearing my throat…… https://wwwnc.cdc.gov/eid/article/10/4/02-0626_article Reanalyzing the 1900–1920 Sleeping Sickness Epidemic in Uganda Abstract Sleeping sickness has long been a major public health problem in Uganda. From 1900 to 1920, more than 250,000 people died in an epidemic...

Doesn’t look like there is good candidate TRPM7 agonist that is selective for this receptor.

I skimmed the article. If she is a neuroscience PhD student at Stanford why didn’t she interview M Monje and M James both of whom work on brain/neuro LC/MECFS issues at Stanford—In addition to the other usual suspects like R Davis, M Davis and M Snyder? Honestly a lot of these so-called...

Do I have to read this? I’m already working on a pretty decent bad mood….

Another potential pharma target is here https://www.s4me.info/threads/altered-trpm7-dependent-calcium-influx-in-natural-killer-cells-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-patients-2023-du-preez-et-al.33840/

“Clinical evidence further supports TRPM7 as a potential therapeutic target to improve health outcomes for ME/CFS patients. Aripiprazole is a promising therapeutic agent for the treatment of ME/CFS that is suggested to reduce microglial activation and associated neuroinflammation via TRPM7 [66].”

Merged thread

https://www.nytimes.com/2023/06/21/opinion/cloning-science-fraud.html?unlocked_article_code=81JDEWmTXSMW4H41xkb4KDvDz3nmm0j1LaKe6MyV3lQVJEhWMmn9SFi2cOnkoeE4hOwy9xfC-_p0_pF6nC8EAGgsxBMDsCsL7KeTWW7-TTt8nbJsx_OrNWvm-2sjoYLiK-jMh5X6uxxCYQX2nKXGHE0ooDTnQF66ZEDcJm5MjBzbQY37_N4v8tNZZzvAmeGnaI4n7br1mzMkA...

https://www.frontiersin.org/articles/10.3389/fnins.2023.1182607/full Introduction: Debilitating Long-Covid symptoms occur frequently after SARS-COVID-19 infection. Methods: Functional MRI was acquired in 10 Long Covid (LCov) and 13 healthy controls (HC) with a 7 Tesla scanner during a...

“That’s right: Two different people independently faked data for two different studies in a paper about dishonesty.”

Nath has stated (I think on the recent NIH call) that they are considering conducting clinical trials based on their findings—to me this is a good indication that they found something.

Yes, Khosla funding is helpful. Apparently there is an Amar Foundation in the UK that is distinct entity from the USA foundation, which is Khosla’s entity? Regarding PB, I am not optimistic about AP’s quest to find viruses—I worry that this is funding that could be better deployed elsewhere...

Nath claims there are potential druggable targets in their to-be-published research. Also looks like potential drug targets in the Avik Roy/Gottschalk/Simmaron work...

Long—haven’t read yet (ALS) Patient-advocacy groups mobilized to demand access to a controversial new drug called Relyvrio. But hasty approval comes at a cost. https://www.newyorker.com/magazine/2023/06/26/relyvrio-als-fda-approval