Search results

Quite honestly, I don’t consider this hype: seems like a pretty measured comment to me. Please note that if you want to wait for a RCT study on LDN to be funded, conducted, have data analyzed and published, please be prepared to wait at least 5 years.

Here is the link to the newsletter https://cortene.wordpress.com/2020/01/ I don't think that they would be proceeding if the drug had demonstrated no positive effect.

Interesting. I remember discussion about amitrip. on the Howard Bloom thread here—the MECFS guy that does 700 pushups.

https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(18)30573-4 Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in b Cells Haven’t read either, but wonder if oligomerization results from overexpression.

Sh*t—well it is still under consideration for macular degeneration—phase 2.

Interesting. What was your treatment @Woolie? Thanks

Thanks. But T cells still come back after Campath treatment. These new T cells are less likely to be “problematic” like the old ones were because the reconstituted T cells are different/better? https://www.jimmunol.org/content/191/12/5867...

Lemtrada underwent review by EMA, who restricted use—final approval by EC pending. https://www.ema.europa.eu/en/medicines/human/referrals/lemtrada https://medshadow.org/ms-drug-restricted-in-europe/ https://pharmaphorum.com/news/european-regulator-restricts-use-of-sanofi-ms-drug-lemtrada/...

@Jonathan Edwards Campath-1H is less dangerous in your opinion than cyclophosphamide? Also what is the difference between Campath-1H (humanized) and Alemtuzumab? Thanks

So maybe there might be some benefit to wiping out abnormal T cells with cyclophosphamide.....

Really poor use of nine people’s time. Any funding and salary time devoted to this should have/could have been devoted to science-based science.

I would assume the difficulty is in getting MECFS brain cells, not just brain cells per se. Maybe they could induce MECFS in the cells with Cipro or the anti-cancer compounds that @RDP mentioned in other threads

https://www.medpagetoday.org/rheumatology/arthritis/83966?_ga=2.265148431.1072804894.1576686559-674435307.1570713348 Journal article here https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-2059-8 Looks like vitality and insomnia improved on this.

Yeah brain cells too. But they would need to get cells from MECFS patients. First cell culture of live adult human neurons shows potential of brain cell types https://www.sciencedaily.com/releases/2017/01/170117141149.htm

Anybody know if this is an established technique/method? Thanks

Ok but how does this altered T cell metabolism affect brain stem function as shown in other research?

@Badpack Is it possible that the plasmapheresis did not remove the “bad stuff” (exosomes) because they were not the right size? I assume that plasma filters are designed to remove specific size antibodies and maybe the “something in the plasma” was too small to be removed by the filters?

https://www.google.com/amp/s/www.the-scientist.com/news-opinion/northwestern-university-stem-cell-therapy-clinic-closes-abruptly--66401/amp Hmmmm

https://www.nytimes.com/2019/12/07/us/dna-bone-marrow-transplant-crime-lab.html Interesting... wonder if pwmecfs could benefit from a bone marrow transplant, especially since all of the blood will have the donor’s genotype. In other words, maybe the blood after transplant won’t have...

Voted ✅