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(I haven't read this study) What's the bet that the nineteen studies were retrospective, with all the bias in reporting that that implies. And, even if it is true that a higher risk of abuse correlates with a higher risk of fibromyalgia, it's correlation, not causation. A higher risk of...

But they still used immortalisation to make lymphoblasts. They do cite the Sweetman paper though, that used lymphocytes and found similar things.

Do all the researchers use lymphocytes/lymphoblasts because they think cells involved in immunity are going to tell us something that other body cells cannot? Or is it just because it's relatively easy to get hold of samples? Is there any risk of the 'Drunk looking for his keys under the...

So, if those differences are there between ME/CFS and controls, in both non-immortalised PBMCs and lymphoblasts, what does that tell us about what is causing the differences? The lymphoblasts will have been frozen, and presumably washed, and cultured, and treated with the EBV, umm, treatment...

A really nice background - it can be hard to get it right, but this one nails it, I think. Background Page 3 typo

@DMissa, nice to see another paper out. What is up next for you and the team? Do you have funding?

From Emerge's 'Lessons Learned from the Health and Wellbeing Survey of Australians Living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 2019': https://www.emerge.org.au/Handlers/Download.ashx?IDMF=609ff625-4eb0-4f5f-b1af-782d08e2b61f The most common support provided was...

On the one hand we are told to increase our self-compassion, and redefine recovery as acceptance of limited lives (and stop bothering the medical system). On the other hand, we are told to increase our self-management skills to work towards recovery by pushing beyond our moral and physical...

yes I did

Reference 105: Cox, B.S.; Alharshawi, K.; Lafuse, W.P.; Ariza, M.E. Herpesvirus dUTPases contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by promoting follicular helper T cell differentiation. JCI 2021. Submitted. Potentially relevant to the reported finding of higher numbers of...

Here's the thread on the 2017 paper: ME/CFS and gulf war illness patients exhibit increased humoral responses to herpesviruses-encoded dUTP, 2017, Halpin, Klimas, Fletcher et al

Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology Peter Halpin 1, Marshall Vance Williams 1 2, Nancy G Klimas 3 4, Mary Ann Fletcher 3 4, Zachary...

Thanks Forbin, I don't think we have a thread for that paper. I'll make one. When I have full-on PEM, I'll typically get a cold sore. For 18 months, I had serial cold sores, as in, I always had one, until I was given valacyclovir tablets. Presumably then, the re-activated viruses are...

I've just done it, and I was a little bit disappointed. It's pretty good. My major concern was that, by mentioning findings from preliminary small studies, it might undermine its credibility. For example, it says that hEDS is a relevant co-diagnosis and that 20% of people with hEDS have...

https://www.rnz.co.nz/news/national...mics-help-plan-world-s-recovery-from-pandemic A International Science Council project - ISC Covid-19 Scenarios Project has recently been launched. The panel of international science leaders include representatives from the World Health Organisation, the...

https://www.rnz.co.nz/news/national/436621/new-zealand-academics-help-plan-world-s-recovery-from-pandemic It could be worth highlighting to both men (and others on the panel) the need to address the burden of Long Covid the countries that have had high rates of Covid-19 will feel, so that they...

Here's a couple of threads tagged with red blood cell deformability and me/cfs: Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome, Davis et al (2018) The Deformability of Red Blood Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - Thesis...

Many effects are non-permanent, it's just a matter of the time-scale. In a hundred years time, my disability will no longer be a problem in terms of 'the working population as a whole'.

We have a number of threads on the forum about cortisol studies in ME/CFS. Try searching for threads tagged with 'cortisol'. (edit - if you go to the top of this thread and look on the left under the title, you will see the 'cortisol' tag. If you click on that, you will see all the threads...

Wow, that's quite a paragraph. If you read it quickly, the overall impression is of quite a lot of people experiencing significant improvement. But, it tells us most people either experience no change or only a small temporary improvement in pain, and 5 trials found that people's pain didn't...