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  1. R

    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    One more question for @Hilda Bastian: Jonathan is one of the very few independent experts who has got involved with the issues under review. Out of interest, will the IAG be consulting any other truly independent scientists with relevant experience of designing and conducting clinical trials...
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    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    Thank you. That would be very helpful, and is what I was hoping for when I asked for clarification above. I agree, but God help us if that led anyone to conclude that we need more GET studies. I’m not even sure how an ME GET study could get ethical approval. I think the general issue of the...
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    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    I’ve only managed to a read a few posts in this thread, so apologies if I’m misunderstanding or repeating anything that has been said. First, thanks to @Hilda Bastian for taking on this task and engaging in this forum. I apologise if I have missed the explanation in this thread but please can...
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    A general thread on the PACE trial!

    This is what I was thinking of (the bit in bold in the second Tweet): https://www.thefacultylounge.org/2016/11/an-open-letter-to-dr-simon-wessely-defender-of-the-pace-study.html: “Finally, you point to your own blog post, which ironically undermines your very point. You compare the PACE Trial...
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    A general thread on the PACE trial!

    There is this from Sharpe et al: https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-019-0288-x To which you and Carolyn responded: https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-019-0296-x However, I suspect that your correspondent may be thinking of something...
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    e-coli infection and leaky gut

    Really sorry to hear that you’re having such a tough time Graham. I wonder if it might be worth contacting Prof Simon Carding at the Quadram Institute: simon.carding@quadram.ac.uk After his Zoom lecture to the Sheffield ME group on gut microbes I posted a question about published evidence for...
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    Coronavirus - worldwide spread and control

    Free to read article in the FT which confirms Jonathan’s assertion some time back in this thread that the UK is bottom of the league on preventing deaths from Covid. UK suffers highest death rate from coronavirus | Free to read FT analysis of data from 19 countries finds Britain hit hardest...
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    My comments to the Cochrane review

    Excellent. Thanks, Michiel. Sorry I've not been able to help.
  9. R

    Simon Wessely on Covid-19

    Listened a couple of times and I’m prettying sure he said “was”. It doesn’t mention whether or not he is in spy SPI-B, but the intro confirms that he is director of the NIHR Health Protection Research Unit in Emergency Preparedness and Response at Kings College London...
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    Coronavirus - worldwide spread and control

    I share SPI-B’s concerns about its advice being censored by the government (before it was later unredacted), but it seems hypocritical for SPI-B to be calling for transparency when it is still hiding the identity of 4 of its members. Unfortunately, the media seems to have dropped its interest in...
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    Coronavirus - worldwide spread and control

    It could, although I would hope and assume that this is taken into account by those calculating the R values. Regardless of the true values, it is still interesting (to me at least) to note that the R value in the whole population can go up when the R value both in care homes and outside of...
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    Coronavirus - worldwide spread and control

    Interesting article by Tom Chivers on Simpson’s Paradox. It explains how, counterintuitively, the R value could go up as a consequence of reducing the transmission rate in the community through lockdown. Not a great sub-heading but the content of the article is very good: ”We should be very...
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    Coronavirus - worldwide spread and control

    To me, that graph is implausible. It suggests that easing restrictions (or adjusting measures) will have no effect on the effective reproduction rate R (or Re). In reality one would expect easing restrictions to increase Re. The angle of the gradient of the downward slope would therefore be...
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    Coronavirus - worldwide spread and control

    Another Covd-19 article by Dr Hammond, which seems to be a little muddled. On the one hand he says he will “never understand” why we stopped testing, tracing and isolating (ie suppression strategy) and then he says we are now stuck with “staged herd immunity” (ie mitigation strategy). But we’re...
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    Simon Wessely on Covid-19

    ‪A more interesting question is why the president of Royal Society of Medicine (who was, and may still be, a member of SAGE) appeared to be so reluctant to follow PHE and WHO advice on self-isolating when his wife had Covid-19. On 14 March Nick Robinson informed listeners to the Today Programme...
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    Coronavirus - worldwide spread and control

    Bonus point to the first person who manages to include ipsedixitism in a paper or letter on Covid-19 or ME/CFS. Extra bonus point to anyone who manages to combine the two!
  17. R

    Coronavirus - worldwide spread and control

    You mean, like the sort of person who might be intimately involved with a clinical trial without actually being listed as a author; the sort of person who might advise on who should be on a research collaborative without actually being a member of the collaborative?
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    Coronavirus - worldwide spread and control

    Ben De Peer is news editor at C4 news: All very familiar. Notable that Anthony Costello, like Jonathan, is emeritus Professor and therefore no fear of repercussions.
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    Richard Horton on Covid-19

    Interesting interview in the FT with Richard Horton, who has become a prominent critic of UK’s Covid-19 strategy: https://www.ft.com/content/8e54c36a-8311-11ea-b872-8db45d5f6714 I’m not a subscriber but I seem to be able read about one FT article a week for free. However, the second time I...
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