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That video (which I agree is really awful in places) makes me very concerned about who they will have evaluating the research proposals. Does anyone know?I suspect the panel will involve Dr Vallings - she's the doctor who recommends singing in the shower in order to tone up the vagal nerve...

Interesting that the paper also mentions mir-142 - that was also found to be increased in ME/CFS by the Brenu paper: In both cases, up-regulation of the two types of microRNA (as found in that 2014 ME/CFS study) might provide protection against a pathogen. It would be great to have...

I was looking for something else and noticed that the miRNA found to be decreased during Coxiella burnetii infection was mir-143-3p. We've seen this miRNA before, in the 2014 Brenu paper on miRNA in ME/CFS. That paper identified three mRNA increased in ME/CFS, one of which was mir-143-3p...

Abstract MicroRNAs (miRNAs), a class of small noncoding RNAs, are critical to gene regulation in eukaryotes. They are involved in modulating a variety of physiological processes, including the host response to intracellular infections. Little is known about miRNA functions during infection by...

It seems that viruses in general target host cell calcium channels in various ways - see here: Host Calcium Channels and Pumps in Viral Infections, 2020, Chen et al

It seems that this disruption of cell's calcium processes is common in viruses. A recent SARS-CoV-2 study noted that the virus affects calcium signalling in endothelial cells. Endothelial cells, especially in the muscles and brain, can live a long time. A lot of ME/CFS symptoms could be...

Host Calcium Channels and Pumps in Viral Infections Xingjuan Chen,1,2 Ruiyuan Cao,2,* and Wu Zhong2,* Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to modulate...

Interesting, SNT, especially in the context of the NCNED suggestions of TRP channels having problems in ME/CFS and the findings and symptoms of ME/CFS that seem to fit with endothelial dysfunction. I haven't read this study yet. From the abstract, it looks as though they are suggesting that...

Welcome to the forum @Sparkly Unicorn. We have the following threads that might be of interest: Post mortem tissue donation and autopsies (Members Only) UK brain banks that accept ME/CFS donors Considerations in establishing a post-mortem brain and tissue bank for the study of ME/CFS: a...

Link to the bio-impedance paper @Creekside mentioned: Bioimpedance spectroscopy characterization of osmotic stress processes in MECFS blood samples, 2023 Fernandez et al

Sure, but it's not the patient who is benefitting. "REAL" - right up there in a long line of acronyms subverting the usual meaning of words e.g. PACE, RECOVER, FINE

I'm well out of my comfort zone on this one, and it looks like a small homemade experiment with some charts that aren't ideal. But, well done to the authors for getting on and doing something and writing it up. It looks to me as though the impedance of a solution with a standardised number of...

They note that the non-inflammatory PASC group still had proteomic differences compared to the controls Despite what they noted about some symptom differences earlier, in the discussion they comment about how symptoms aren't good at discriminating between people in the two groups they...

I'm not up to much this afternoon, and have run out of steam to copy charts. But there do look to be some interesting findings. Have a look at the Figure 3 charts. On symptom differences:

Further on the heterogeneity of the sample, they found that the Long Covid sample divided into two clusters, one of which looked like the healthy controls (on the left in the Fig 3a chart below) and one that was almost completely different (on the right). Pink is PASC, grey is healthy controls...

Indeed, that's really disappointing. To not be anywhere matched on sex or age surely is a problem in proteomics? The PCA (Figure 1a) describes relatively little of the variance (PC1 explains 21% of the variance; PC2 explains 6% of the variance), and there's no clear separation of people with...

I agree. CoQ10 sounds like something that should help, supposedly covering the very common hand-wavey explanations of ME/CFS - inflammation and mitochondrial dysfunction. But there's no evidence that it, on average, does help in any meaningful way. People can sort out for themselves whether...

The approach to fatigue and ME/CFS specifically in Newcastle seems to be variable, it probably depends enormously on which team you are talking about. There are definitely some problematic attitudes there, and I personally doubt that Julia Newton has done much to counter those attitudes. There...

I haven't read the paper to see how strong this finding is. Could be interesting to look for these lipoglycans in people with ME/CFS, with a longitudinal analysis covering good and bad days.

What is that opinion based on? This paper, the IDEA-FAST project (which seems to have taken a broader approach to assessing the utility of wearables), or direct knowledge of what the group is doing? I assumed that this group probably played a role in NICE approving five devices for use in...