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This paper is mentioned on other threads: Functional Neurological Disorder (FND) - articles, social media and discussion Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis, 2022, Heckova+ This thread has more...

There's some really nasty patient labelling going on here, where differences in brain activation that are poorly understood are so often bent to suit a 'not really sick but at the same time, sick' narrative. We've seen the poorly done studies of brain imaging; it's no surprise that the...

As I mentioned elsewhere, papers like this are an interesting reflection of psychosomatic medicine proponents scrambling to reposition themselves as the evidence comes in for physical, medically treatable causes of various health conditions that have carried the 'functional' label. Here, the...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418342/ Abstract Neuroimaging has been pivotal in identifying and reframing our understanding of functional movement disorders. If accessible, it compensates for the limitations of the clinical exam and is especially useful where there is overlap of...

It looks like the authors are tying themselves up in knots as etiologies move from essentially magic to a situation where the pathology is understood. There are sequences of re-positioning that don't really make for coherence. Thread for discussion of that paper here.

These are different things. I think many people with ME/CFS can at times experience symptoms during muscle work, but also experience the constellation of symptoms at a later time that is PEM.

Googling hypothalamic phospholipid liposomes, I see they are made from the brains of cows. They appear to have been a significant thing in the 1980s with papers suggesting they be used for depression, menopause and the usual collection of other conditions subject to poorly evidenced miracle...

I'm intrigued to know whose hypothalamus is providing the phospholipid liposomes. The paper is paywalled for me, the webpage says 'You have clicked too much', which is probably true, at least for today.

A few more measures from the exercise group ***** IL-10 Again, HC on the left, ME/CFs on the right. Bars join pre and post exercise results. IL-10 significantly increases in ME/CFS but not in HC. IFN-γ and TNF-α were also looked at, but it is reported that there were no significant changes...

I'm not yet convinced that all of the sex differences really are as significant as some researchers suggest. I think sometimes the differences are cherry-picked sampling artefacts. But yes, the sex imbalance in the sample here is odd given the researchers aimed to look at humoral immunity...

Exercise sample So, unfortunately, anything found in this sample is going to be discounted by the very small sample size. But these researchers do win points from me for using the same y axis within each pair of charts. The healthy controls charts are on the left, the ME/CFS charts are on the...

A bit more on the sample selection I'm not sure how well matched the samples were. They don't say they attempted to match. Reported mean ages are similar, but there is considerable variation. The percentage of females differs quite a lot, especially in the exercise cohorts where perhaps it...

Good initial sample size: 131 ME/CFS (Fukuda +CCC+ other requirements such as acute onset), 86 healthy controls Smaller sample size for the exercise challenge: 9 ME/CFS (Fukuda only); 7 healthy controls Plasma samples immediately before and 15 minutes after a VO2max exercise challenge (A bit...

Instead, I think it's reasonable to argue that the fact that the two LC groups showed very similar persistent symptoms suggests that seropositivity to SARS-CoV-2 doesn't have much to do with the etiology of Long Covid.

Wonderful presentation and question answering by Gracemarie Bricalli - approx 10 minutes all up.:thumbup: I hope that we have Gracemarie as a member here. There's an interesting discussion about pain that follows, there's a mention of fibromyalgia and gender issues. Also a discussion of the...

I have found rhabdomyolysis interesting in the context of ME/CFS before, given the symptoms of muscle pain and stiffness. I can get a series of muscle cramps. Is that common in ME/CFS? I have noticed I periodically get dark-coloured urine, not dark yellow, definitely more red-brown, that does...

Thanks for bringing this to our attention @mango. I think it is a condition that people with ME/CFS symptoms should consider. It sounds as though the condition is under-diagnosed. There seem to be issues with histology that mean that the condition could be missed: There is a wide...

McArdle Disease, 2023, Khattak and Ashram

Further posts related to the dietician's queries have been moved to a new discussion thread: Issues to consider in dietary intervention studies in ME/CFS

Excellent points @Trish, @Ravn and @Midnattsol. As well as ensuring that participants do in fact have ME/CFS, it might be necessary to have even more detailed selection criteria. For example, not all people with ME/CFS have dietary sensitivities, but some do. Not all people with ME/CFS have...