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Background: Fatigue and cognitive complaints are the most frequent persistent symptoms in patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to assess fatigue and neuropsychological performance and investigate changes in the thickness and...

Abstract Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real‐time magnetic resonance imaging, beat‐to‐beat physiological monitoring, and orthostatic stress testing...

Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombosis) and the inflammatory response...

New research uncovers the role of mast cells in Covid-19, and mast cell stabilizers could be efficient and safe in tackling the blockage of blood vessels. https://www.birmingham.ac.uk/news/2022/targeting-mast-cells-could-be-beneficial-to-treat-covid-19-patients

Abstract Beyond their pulmonary disease, many COVID-19 patients experience a complex constellation of characteristics, including hyperinflammatory responses, autoimmune disorders, and coagulopathies. However, the pathogenesis of these aspects of COVID-19 is obscure. More than 90% of people are...

I can testify that my baseline went lower after a reactivation of HHV6 and EBV from taking immune modulators. I also developed orthostatic impairment. This occurred 11 years after ME onset

My cognitive assessment would show huge differences from a lying down and upright position.

Me too. At least they won't force to exercise ;)

You can ask the author of this article on Twitter. This tweet goes back to 2019.

If this is the case then why doesn't it prevent LC or death? Should we get rid of vaccines in this case and give out yoga mats? :emoji_thinking:

I called last to week to book a home visit but I haven't heard back yet. If I don't get a call back soon I'm going to assume I didn't leave my phone number on their answering service. Wouldn't surprise me.

Are you aware that Jeff Wise wrote a book about the mechanisms of fear in the mind, and how different parts of our brains react? He looked into the neurology and the psychology of fear situation. Not surprising that his views on fear of exercise and PEM are part of his narrative. He said he...

Abstract Assessment of micronutrient (MN) status is of particular importance in patients who require medical nutrition therapy, especially those requiring parenteral nutrition. Blood testing is generally the only tool available in clinical settings to assess MN status. However, using plasma or...

Summary Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial...

Melatonin and LDN put me in an agitated depressive state. Made my sleep worse.

Modulation of autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction, 2022, M. Khawar Ali et al Abstract Patients with a defecation disorder may not evoke a normal defecation reflex, or the reflex may be excessive, as a...

"Komaroff listed only 3 things found in ME/CFS (ion channelopathy, exhausted NK/T-cells, craniocervical instability) that have not been found yet in long COVID – perhaps for lack of looking". Does anyone have a figure on how many people diagnosed with ME had craniocervical instability? n=3...

Objective: To assess the prevalence and burden of autonomic symptoms in migraine, and determine the relationship with migraine frequency. Background: Autonomic symptoms in migraine have been theorized to occur in the setting of inter-ictal sympathetic hypoactivity and hyper-sensitivity. There...

Summary The intestinal barrier, which primarily consists of a mucus layer, an epithelial barrier, and a gut vascular barrier, has a crucial role in health and disease by facilitating nutrient absorption and preventing the entry of pathogens. The intestinal barrier is in close contact with gut...

Management of patients with hypertension and orthostatic hypotension. Parallel progress: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19113