Search results

Except that the common cold is the one infection nobody seems to have linked to ME? Nobody much says 'well blow me down, I just had an ordinary cold with a runny nose and ever since I have been unable to do anything'.

I think the problem is that if PEM was due to dying cells we would expect a rise in CRP and platelet count etc.. ME might not follow the usual rules but we can only get the plausibility of sequence like the by the rules from other conditions. Poor blood supply muscle is a well known clinical...

There are a number of things about the paper that seem peculiar. The abstract ends with 'The discovery of these biomarkers pointing to significant and systemic endothelial inflammation, represents an important development in ME/CFS research. It also points at novel treatment strategies using...

The Amazon.com site does not add up either. One positive review seems to be 61% and lots of negative 39%.

It IS suspicious. But no worries. Those that laugh last laugh longest. As Ms Fox may discover.

Yes, I agree. I have been wrong before but these results do not look real to me. And I don't think they make any sense in terms of the clinical picture of ME.

I had to look that up. Apparently from Stephen Colbert? Somehow it sounds as if it's wearing a gingham frock.

Maybe that says it all - a term designed to 'sidestep' any meaning that might give the game away.

There is quite an interesting problem here. Almost everyone has had Covid now so anyone presenting with new muscle weakness will be 'post-Covid'. This is presumably a study of patients with enough evidence of muscle disease to deserve a muscle biopsy - the evidence need to be quite good usually...

But very good, @adambeyoncelowe. It should be hard to read that and not see what an idiot Fox has made of herself. No doubt some have the resources in mental acrobatics to not see but you have set the bar pretty high.

I actually doubt this. I think it unlikely that the sort of change now being given the buzzword 'neuroinflammation' will turn out to be the cause of anything much. Glial activation occurs in most forms of brain pathology as a secondary process and may not contribute much to clinical problems...

I think that I jut too vague to be useful. And we know what the effect of brain injury are from the more severe or repeated cases and they are not like ME. You can get dementia and Parkinsonian features but not ME.

I think you have to be aware that clinical definitions of diseases are not deigned to be a comprehensive description. They consist of the features that distinguish that condition from other problems or normality. In other words, no definition of multiple sclerosis includes the inability to...

I realise that a lot of PWME get treated a hypochondriac but the literature on ME/CFS documents long term worsening in a significant proportion. If you are talking specifically about exercise causing long term deterioration that is a different matter and something we do not have any reliable...

But surely that is their job - only to pay out on their client's behalf if there is reasonable evidence of causation. Otherwise surgeons would be uninsurable because they would be blamed for all sorts of things. We now have a system in the UK where if you have an accident the repair garages hand...

This is a retrospective questionnaire based study recruiting from wherever they could find people, including forums and support groups. Not only is this likely to be very unreliable but it is an ideal way to generate memes that get further entrenched with further studies. It is the way to...

This looks like a write up of a trainee fellowship project.

If the desire is to have categories used by health care professionals that recognise patients' problems then Ramsay is not relevant since health care professionals no longer base their diagnosis on his description. They recognise long term deterioration.

I admire the extended eloquence of my friends David and Brian. I only managed a couple of sentences, but we are of one mind it seems.

The annoying thing is that there is no zero star rating allowed. So these 2.6 and 3.4 ratings should really be about 1.8 and 2.7 out of 5. And of course one people might think it should get a negative rating...