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I'm not sure that Simon's account is quite right though! Hypertonic solution should make cells shrink, not swell. If the impedance has anything to do with the cell it must be something to do with a change in the structure of the membrane I think.

It might be insurance against injury from a specific cause though - surgery or accident etc.

An interesting interpretation but you wouldn't need a nano needle to show that. You could use the electrodes we had in school physics. Seems nobody knows what this is supposed to be about!

For me it is more that I do not know why this measurement should be of any interest. It is a bit like having a person in shock. If you measure impedance on their skin it may be low because they are sweaty but it would be more useful to check their pulse and blood pressure.

I think I worked out not. You would need a concentric electrode to do that - like a Jack plug with one electrode at the tip and the opposite on the hilt. The nano needle isn't a needle but a bar with two electrodes side by side. If cells are unhappy you expect their permeability to increase and...

The SPECT thing has never been validated and for that reason alone I am sceptical about Dr Hyde's ability to gather reliable evidence. A history of toxin exposure may be of interest but whether or not it is the cause remains speculation. In other conditions we have much stricter criteria for...

All of those are true but I don't see them having relevance to a possible link between injury and ME.

Not in any known sense as far as I know. Yes, macrophages will pass into an area of tissue damage but they do that every day to tidy tissues up. By activating the immune system people usually mean stimulating a specific antigen response and there is no reason to think that would happen...

The irony for me I that I think that there are illnesses (quite different from ME) that justify a term like FND but if people like the are involved I see that a a very powerful reason not to have the category.

I think a link to surgery itself, or anaesthesia, can probably be discounted. If it occurred it would have been reported by now, considering the hundreds of millions of anaesthetics that have been given. They haven't actually found a route in GWI, although the link to genes involved in...

I can PM a PDF. It is long and I don't think I can post it on open thread? It is drivel on steroids, on more steroids. It could win the all time prize for Pseuds Corner.

I don't honestly think there is any tangible evidence for ME being triggered by non-infectious factors. I cannot think of any very plausible mechanism. That does not mean it does not occur but I think vague ideas about disrupting neural circuits or perfusion should be treated with scepticism...

I wonder if after it was published the author realised how much the argument disappears up its own backside? But no, I guess not.

Well, so if three members with extensive clinical experience did leave in protest is that so surprising if the independent review found that their treatment was a lot of old cobblers? Let's have some human reality in here. Would the faith healers have resigned in protest if faith healing was no...

Random bullshit does tend to cut across loads of stuff.

Pandemic due to a pandemic? Jordi Robert Olalla After two years of pandemic, to the many doubts that have arisen in prevention, vaccination and treatment in the acute phase, we now have to add the doubts being generated around the understanding and classification of the complications of the...

The first author runs a physio training company that pushes exercise as a basis for whatever. This is just peudophilosophical drivel. I doubt that an article in this sort of tortured language will make much difference. On the other hand it looks a if there is a widespread campaign going on to...

Isn't that pretty much by definition the case? The question is why we should be interested in dielectric properties of cells or cell membranes perhaps. What change in useful behaviour might that be indirectly measuring. The original paper I found opaque on the simple geometry of the situation so...

Unless the initial findings were an artefact of the way the experiment was set up, which so often happens in preliminary studies.

Yes, that is what they have been saying, but what they are measuring is a change in behaviour of cells that seems to be due to what is in the plasma. Impedance seems to me a crazy thing to look at if you want to look at changes in cell behaviour. There are much more routine things to look at...