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It might possibly but as far as I can see no real link ha been down here. We know KIR+CD8 T cell police other immune cells. That I what KIR and CD8 are for a ha been known for decade. But that doe not mean that a lack of the function is the cause o any common autoimmune disease. It might be...

To be honest I don't know what he means. Firmness involves compression or manipulation so is a macroscopic phenomenon. Muscle biopsies are pretty squishy normally and at least in the old days were carefully laid out on a card and then processed for sectioning and not prodded about. I don't think...

For me the problem is that the nano needle never really made sense. Measuring impedance in a suspension of cells might measure something but it is very hard to see how it would be a useful way to measure it rather than something much more routine. I forget the details but it looked rather as if...

It sounds a positive move. Will there be anyone involved who actually knows how to get things done in research though? That may seem a silly question but most people in the politics of research don't. The MRC seemed to follow thee right path to DecodeME but this seems to be more all-comers fro...

Yes, well, we can see that, since nobody who had checked the facts at all would have written chapter 3.

In what sense do you think that the current classification is not working? Long term deterioration is an accepted feature of the natural history of ME is some. One could call it progressive ME but as a clarification rather than a new category I think. If long term symptom exacerbation is...

I think the problem with tinnitus is that it can be switched on or off by attention mechanisms that act both short term and long term and are not necessarily consciously controllable. The most remarkable thing for me is that I had tinnitus for thirty years - it was always there if I asked...

No, there is no irony in what I am saying. That is why I find it so strange that you should find it. I am simply pointing out what is likely to be an own goal. As far as I can se in the USA because the CDC or IOM or whoever did not stick to clear arguments things are likely to unravel back to...

Not sure what that means. I am not dismissing the power of anecdote but anecdote is not in itself enough. I have no idea what that means either. I may seem pedantic but it seems there is a problem here with the most fundamental issues about how reliable evidence is gathered. You need...

Absolutely not. How can one person have any experience of whether or not their symptom is associated with a condition they are known to have? Association is established across a population, not in an individual. We are talking about association in the sense of a statistically higher rate of...

Yes, this is basically what I was suggesting. The GWAS does not look for every known polymorphism at the individual base level (SNP) but it is designed to cover every part of the genome so that linkages should be picked up because the SNPs that the GWAS does cover are quite closely spaced in...

For an individual person IgM values in this sort of situation probably mean nothing much. There was a hope that IgM versus IgG would indicate whether infections are still active or not but for EBV at least it is not clear enough to be useful as I understand it.

Of course not but that is all beside the point. I am talking about the tactics of solving the problem. And plugging weak evidence on the biomedical side is still a huge tactical problem for the ME community. It's a bit like an amateur tennis player playing to Roger Federer's crosscourt...

I think it would tell us a lot. Particularly if the detail of the phenomenon associated with ME was looked at. Tinnitus is not really 'not well understood' at the level ME is. We know that tinnitus involves dysregulation of signal flow in the auditory nerve. We know that the problem can be...

I think this sort of approach should be looked at very critically. Tinnitus is common, period. I have it and so do lots of people I know. And so is hearing loss. Did the Dowsett paper include controls and was it carried out in such a way as to avoid subjective bias - I bet not. And since...

No it isn't. Lots of people with ME may have tinnitus but there is no evidence that tinnitus is caused by whatever causes ME. This is exactly what this forum should not be about - assuming that symptoms can be attributed to ME when they may well be due to something else that is important. One...

Copied post No it isn't. Lots of people with ME may have tinnitus but there is no evidence that tinnitus is caused by whatever causes ME. This is exactly what this forum should not be about - assuming that symptoms can be attributed to ME when they may well be due to something else that is...

And it suggests it may not. I think this conclusion is unjustified. If we are trying to raise the level of evidence and discourage the publication of meaningless data, especially when based on social media and questionnaires, then this is unhelpful.

New onset one-sided tinnitus should be investigated even if often no cause is found. It is unlikely to have anything to do with PVFS or ME. I would recommend getting specialist advice.

In answer to the original poster, no, this is not reputable. It is straightforward misrepresentation of reality - i.e. pseudoscience. The appearance of various scientific sounding words means nothing. Nobody has found any evidence of a cytokine shift in ME/CFS of the sort claimed. It is a pity...