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    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    I'm sure my microbiome would be abnormal. There are so many foods and food families I need to avoid that my food diversity is greatly reduced. For many PWME, reduced activity levels might also affect the microbiome. Studies such as this really should use controls with similarly reduced...
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    Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in [SLE], 2021, Anderson et al

    If they're studying the neurological effects of QA, I don't think they should be using serum samples. Most QA in the brain is produced locally. The correlation they're probably measuring is from the disease affecting cognition via local QA production also affecting QA production elsewhere in...
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    Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of ME/CFS, 2021, Du Preez, Staines et al

    Seems like a good candidate for further investigation. My brief skim made it sound like magnesium supplementation should have an effect, but I haven't noticed any, but maybe it's not that simple.
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    Is ... COVID-19 causing an increased risk of psychological distress, psychotropic prescribing or sleep and fatigue problems? 2021, Abel, Chalder et al

    If the goal of a study is a desired outcome, for whatever benefits to the authors, it's all a matter of choosing experiments or carefully selected data that supports the outcome. A well designed study of something silly, such as whether slugs move more erratically during a full moon, is...
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    Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla, 2021, Godlewska et al

    I can't recall anyone claiming reduction in ME symptoms from taking lecithin (leads to myo-inositol ) oranges or cantaloupes. Oranges (a source of myo-inositol) were the initial immediate trigger of what became my ME, although that might not be related to myo-inositol (but can't rule that out).
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    Adverse event recording failed to reflect potential harms: review trial protocols psychosocial interventions, 2021, Papaioannou, Cooper et al

    Good. It seems pretty obvious that there's a need for that.
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    [Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome], 2021, Feng et al

    We can't even clinically verify ME in humans, and going by questioning humans (who can communicate in words) is fraught with difficulties, so any claims for rats with ME seems kind of meaningless.
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    The ‘medically unexplained symptoms’ syndrome concept and the cognitive-behavioural treatment model, 2021, Scott, Crawford, Geraghty and Marks

    Doesn't everyone suffer from post-exertion fatigue? I call it: "Getting tired". :) For ME, I prefer to use the term 'fatigue-like' instead of fatigue, which is a poorly defined term in any case. Are there any definite clinical measures of normal fatigue? For a normal, healthy person, does...
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    Patient perceptions of infectious illnesses preceding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Jason et al

    My ME also started with ‘I have felt that the flu is coming'. The muscle aches/body tenderness and overall malaise seemed identical to previous flu infections. However, the next day I felt fine again. Then a week later, the same feeling occurred, and this time I felt feverish and really...
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    Shared Individual Formulation Therapy (SIFT): an open-label trial of a new therapy accommodating patient heterogeneity in [FND], 2021, Gutkin et al

    The trick is in how you define 'works'. For psychology/psychiatry, you just choose some unquantifiable targets and choose your questions to give your desired results.
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    Patient perceptions of infectious illnesses preceding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Jason et al

    One problem is that if you want to find a cause of something and there's no way to prove or disprove the cause, it's fairly easy to find something to blame. I had a tetanus booster some months before I developed ME. Was that the cause? There's no way to test that. Did I sneeze at least once...
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    Number of musculoskeletal pain sites leads to increased long-term healthcare contacts and healthcare related costs, 2021, Mose et al

    When I saw the thread title, I checked to see whether they meant that the more pain relief web sites available, the more people would seek medical help for pain. The actual research finding was no less silly. :rolleyes:
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    Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation, 2021,Becattini et al

    I wonder whether this might provide some useful markers for ME.
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    Complement activation in a model of chronic fatigue syndrome, 2003, Sorensen et al

    I have a couple of type I allergies (Timothy grass pollen and what is probably fungal spores) but neither affects my ME symptoms. I think that for some people, type I allergic reactions might indirectly worsen ME symptoms, possibly through extra cytokines or depletion of resources or some such...
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    Will it ever be reasonably safe for PwME to go back into society, post-Covid?

    Alberta was quick to declare the emergency over and drop all restrictions. Now they're admitting that they were too optimistic, and the big surge in cases is filling the ICUs. I haven't noticeably changed my lifestyle due to Covid. I went to town only when I needed to before Covid, and still...
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    Asthenic disorders as a manifestation of chronic fatigue syndrome, 2021, Putilina

    I really don't consider 'aesthenic disorders' as being a superior term than 'central fatigue'. Central fatigue isn't well-defined, but at least it has some definition. How about we stop trying to rename things that we can't clearly define? If we manage to find a clinical cause of this...
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    Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Result in Sustained Improvement in ME/CFS - Pereira, Bateman et al, 2021

    While the trial doesn't seem to show strong evidence to support the claims for the drug, I haven't seen any dismissal of the hypothesis for the root cause of ME. The drug might fail to work as theorized for any number of reasons. I hope that someone follows up on the hypothesis itself. Maybe...
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    Fluctuating food sensitivities, theories?

    Niacin gave me suicidal thoughts, and hot flushes when I took an actual tablet of it. Maybe try a niacin tablet or some food rich in niacin and see whether that causes any of the symptoms. As others have said, changes to gut permeability or microbiome could explain the responses to various...
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    A comprehensive review of approaches to detect fatigue using machine learning techniques, 2021, Hooda

    Since yawns are contagious, does that mean that fatigue is? :yawn: I'm surprised that they didn't use muscle movements or posture as features. I'd expect frequency and speed of movements to decrease with fatigue. My question is: how did they determine the accuracy of their fatigue...
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes, 2021,Crewe et al

    Some people wonder why researchers haven't figured out the root cause of ME. Well, the body is immensely complex, with all sorts of subtle but important interactions. We read about these new discoveries, but how much is yet to be discovered?
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