Search results

The 'come up with therapies' part may be a wee bit optimistic, but we won't figure ME out without data, so the more projects collecting potentially useful data, the better. I believe that ME is primarily neurological (with downstream effects on the body), so I support studies of the brain.

"Haze figuring" sounds like if fits ME. "My thoughts get lost in the haze." :unsure:

Paid work for the researchers? It seems unlikely that it will benefit patients more than just telling them to pay attention to changes in symptoms and keep a food/activity/symptoms journal. We all differ too much in our symptoms and responses to factors for any general findings.

These specialized microglial cells might respond to the same triggers that regular ones do, so the neuroinflammation found in ME patients might involve these cells too, messing up blood flow.

I got PEM from driving. The worse the driving conditions, the worse the PEM. Driving in the dark, in heavy snowfall, on icy roads, triggered severe PEM. The same drive during a sunny dry-road day usually didn't. I think it was the cerebral processing of inputs and the stress of the increased...

I tried CoQ10, with and without supplements, and with a reasonably healthy diet ... and didn't notice any effects. Even well-conducted trial results can be interpreted in ways that don't match reality very well.

"You appear to be my healthiest patient."

I didn't bother to read the full paper, but the abstract sounds like they came up with a bunch of excuses for why a lack of evidence supporting the hypothesis shouldn't be considered as a lack of evidence.

Wouldn't scoring on the test be affected by physical symptoms (concentrating less because you feel lousy) and changes in activities during the day (being less active due to feeling lousy) and changes in lifestyle (vegging out in front of TV rather than reading, crafting, etc)?

I did get worse symptoms from meat fats, which I thought was from palmitic acid (based on the responses to different foods). Carnitine blocked that. I wonder if it would affect their experiment cells too.

Yes, Moderna. I'm heading in for the shot today.

When I booked my second vaccine appointment, I was offered either a second dose of the Pfizer vaccine, or a dose of the other one (starts with an 'M'), which is supposed to be just as effective. I did ponder whether ME might cause problems with a different vaccine or with a second dose of the...

Desperation? No, the psychiatrists would probably come up with a fancier and even less meaningful term.

It would be interesting to compare those with a modern sampling of typical underexercised poor diet subjects. :)

Going by the photo, '10 degrees cooler' is due to being more reflective than wood that's painted red or green (fairly poor solar reflectivity). What I'd want to know is the temperature difference between his paper and white paint (regular or designed for solar reflectivity). My guess is that...

So, did they come up with a clear, concise, quantifiable (and verifiable) definition of insomnia that everyone studying insomnia can agree to use?

I don't know of any actual studies, but I think it would be hard to prove that food sensitivities do not occur. Our bodies are amazingly complex in their biochemical interactions, so we all have different sensitivities to various chemicals. I was quite sensitive to nightshade toxins (potatoes...

The triggering and recovery of PEM would have different subsets, but the point is to discover the mechanism of PEM: whatever it is that changes as the result of triggering. That is likely to be the same for most PWME and maybe long-covid. Even if the reliable, consistent PEM subset was small...

Does anyone know whether long-covid PEM is consistent? Many PWME can reliably trigger PEM and have it show up a consistent x hrs after the exertion and have it last a consistent x hrs after it shows up. If so, then maybe we can get long-covid researchers, with their better funding, to do the...

I do believe that my ME involves abnormalities in my kynurenine pathway. Too much QUIN would probably explain some (most) of my symptoms. I think niacin made me feel worse because without dietary intake of it, my enzymes would convert more of the excess QUIN into niacin.