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One solution is to require 'placebo effect treatments' to include a disclaimer such as: "Works just as well as snorting gummy bears! <or some other obviously silly treatment>."

Why should the same old sh*t work now? Answer: because it's got a new label!!! :rolleyes:

"We who make money selling physiotherapy services have a hammer. ME looks like a nice profitable nail."

My ME has responded to several species of longer-chained fatty acids. Palmitic made me feel worse unless I also consumed enough carnitine. CLAs improved my sleep. I haven't read anything to indicate that longer-chained FAs get broken down into shorter ones, so that's probably not how they had...

An easier solution to this problem: just redefine psychology as 'not a valid science'. If they're not following the rules and procedures of science, they don't qualify. Libraries can move psychology books to the 'fiction' section. Has psychology provided any really useful results?

My cognitively-induced PEM would occur 30 minutes to an hour or two after the trigger (chatting, driving in poor conditions), so I don't think there's enough time for housekeeping to fail, and it definitely rules out the 'sleep maintenance failure' hypothesis. I think my physically-induced PEM...

It could be that some of these genes bias other functions in the body that makes it more likely for us to get stuck in this abnormal state. Thus it might not be "this gene causes ME" but rather "this gene and that gene and this diet and this exposure to this toxin as a child, plus this stressor...

21 subjects, with vague sets of factors (fatigue and diet), and they're trying to claim meaningful results? I expect if they redid this with completely random subjects, they could find some similar correlations, with the astonishing conclusions that one group was suffering from snake venom or...

I agree with your feelings about "thinking happy thoughts" is supposed to be such a great cure-all ... without reliable proof. Likewise about creating explanations without proof, which some people then hold onto fanatically. For ME, I feel that my 'think myself better' function is broken. How...

I think ME screws up neurological signalling, more or less at random, so having your satiation signals messed up seems plausible to me.

I see this as the sort of 'bit of knowledge' that might trigger a flash of insight in some other researcher. "Oh, that might explain why ...".

By 'it', I meant the connection between allergies and dietary fibre. If there was a significant correlation, I would have expected someone to notice that: "kids who eat fibre-rich foods are less likely to develop allergies than ones who eat a fibre-poor diet." If the correlation is minor, it...

Are there no ways to intentionally modulate this type of gene expression? Some drugs, cellular isolates, nutrients or whatever? I can imagine giving a test subject doses of various things, and one of them resulting in the patient saying "Wow, I feel healthy again." Even one that gives a...

Interesting, but if it's correct, I wonder why it didn't show up in statistical analysis of allergies. Maybe there are so many factors determining this process that preventing allergies won't be as simple as adding more dietary fibre. "Fruit Loops! Now with added allergy-preventing fibre!"

Decide what figure supports your paper best, then search all available data for the best match?

I agree with Ravn about immune activation rather than the cause of that activation being the trigger for ME. Some people might be primed to enter the ME state, and it doesn't matter whether it's a microbe or physical injury (even microtears from normal exercise); what matters is that some...

My tinnitus started well before my ME. I didn't notice any drastic change in it when I did develop ME. I think there may be a link between neuroinflammation and tinnitus, and ME seems to involve neuroinflammation, but tinnitus isn't unique to ME. I like to blame ME for all sorts of things...

It certainly does sound like a major boost to 'seeing' what's going on in brains. Even with its limitations, some 'before, during and after PEM' scans might reveal something useful.

Yes, I wasn't under any elevated pressure when I developed ME. I'm sure plenty of people were also living a low-stress lifestyle when something triggered their immune systems which in turn triggered ME. How much support is there in the research community for the reliable identification of...

An immune activating event somehow triggers some neurological changes, and some sort of feedback mechanism keeps the body locked into this abnormal state. I figured that out many years ago, without a medical degree. I don't have any solid evidence of the mechanisms involved ... and neither do...