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Unless it's a pet project borne out of personal obsession, like the weird and unnecessary 'review' of microclot treatments. Even though Cochrane only reviews pragmatic trial evidence, and there aren't any pragmatic trials, or any trials, or even treatments, since it's still at a research stage...

There is no such thing as stress biomarkers. In almost all instances where 'stress' is used, they can be substituted with exertion or other labels and actually gain meaning, especially if the meaning respects the context. However much they want to make cortisol a marker of stress, the...

Somehow, I very much doubt that the authors of the rant had to pay that amount. Somehow.

Not sure about that. I think they do understand it, it's just that they reject the validity of the outcome when it goes against them. They very much like the NICE guidelines when they go their way. In fact for years clinicians pretended to be bound by them when they recommended CBT/GET, and now...

Posted because the NEJM is generally regarded as the best medical journal. It's disappointing to see the literal definition of ME/CFS without it being mentioned, and this being Dr Al-Aly suggests that the NEJM rejected it being mentioned, but obviously any progress in LC will benefit us so whatever.

Long Covid and Impaired Cognition — More Evidence and More Work to Do https://www.nejm.org/doi/full/10.1056/NEJMe2400189 The cardinal features of long Covid include fatigue, dysautonomia (or postural orthostatic tachycardia syndrome), postexertional malaise, and cognitive difficulties that are...

Again reminding that in the original design validation, the completion rates were 98% and 96%. Failing the easy task here clearly shows a strategic choice based around the way the 'game' was designed, which invalidates the test in yet another way. And yeah basically they threw away HV F's...

Seems worth the try to me. I am quite sure he would see it as a misuse of his test, and if he cares about its validity, he should be motivated to at least say so.

I thought SaS was serious. Were they always like that? Toby Young is a right-wing troll, no serious person would have anything to do with this fool. It says that Garner is on the board of trustees of SaS. That really makes it a clown organization. And these people present themselves as...

Fake scandal on page A1. Relentless prime-time TV coverage for weeks. Retraction on page A28 of the week's least-read day months later. They know they'll always get promoted for their lies, and countering of their lies never get any air. That's why they don't care. I seem to remember the rant...

I want to contribute something, I just don't know what to say. Research is not a "look for that" thing. It's a process, arduous and requiring a lot of insight and creative thinking. "Do your job" is also not something that makes sense as a research priority. Neither is "do better". What is...

Richard Horton, most famous for being the guy who published one of the worst cases of research fraud, has said that in his opinion half of all scientific papers are wrong. Not in his journal. Nope, not him, as editor-in-chief famous for one of the most harmful examples of that in history. Not...

This is very confused. It starts out by saying that it's not realistic to require a known pathology for every illness, because it's just not feasible. And this is known, especially in toxicology, sometimes you need to know what a patient has come in contact with or you'll simply never be able to...

Super interesting thread from Todd Davenport about the anaerobic threshold differences between patients and volunteers, and how obviously different the demands from moderate activity are between the patients and controls. Something they seemed to have paid no attention to. The study considered...

It feels pretty normal that it has failed to deliver considering that we pretty much only understand the parts of the genome that code for proteins. The belief is no longer that most DNA is 'junk', but obviously the plans for an organism have to be part of the genetic code, and we understand...

This is delusional. These people have no connection to reality. Self-diagnosis is a consequence of systematic failure. It should almost never happen, but because health care systems are failing, in the case of chronic illness deliberately, people are left with no choice. It's only happening...

I think we have a basis to demand that. This entire test and any discussion of it needs to be removed from the paper. It will still be a largely useless study, but at least it will not cause more harm. I don't have the mental/energy bandwidth to do this, but it should be rather short as the...

That explanation is complete BS. When you have the flu, the real flu, not a mild cold, there are things you certainly can do, like get out of bed to grab a glass of water, or answer the door, then probably forget that you even did that. But you certainly can't perform at work, cannot go out and...

Given that the test was designed to be about reward, not performance, and features a 96% completion rate for the hard task in its validation experiment, I don't see how this doesn't invalidate the entire test. Among many other reasons. This is much farther outside of the test's criteria than the...

If this were a test of ability, it could be defended. But this was a test of motivation to a pointless task, and it seems to me like tester F made his effort preference clear enough. Assign a stupid test, get stupid results. When the test is about motivation, "I don't want to play, this is...