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"March 11 marks 3 years since WHO declared COVID-19 to be a pandemic. While the world is determined to move on from the acute phase, at least 65 million people are estimated to struggle with long COVID, a debilitating post-infection multisystem condition with common symptoms of fatigue...

Introduction Functional neurological disorders (FNDs) are a common cause of neurology consultations.1 Dissociative seizures, motor and cognitive disorders are the main phenotypes. Diagnosis is made on positive terms: signs of inconsistency, incongruence and variability of physical signs with...

"‘Functional disorders’ are described as resulting from pathological changes in bodily ‘function’ rather than ‘structure’. This conceptualisation is thought to offer an explanation as to why standard medical investigations are commonly unremarkable. Other conditions that fall under the umbrella...

In the UK alone, there are an estimated 1.5 million people experiencing symptoms persisting over a year after infection with SARS-CoV-2. 72% report that their symptoms interfere with daily function and 15% (or around 340 000) report that their daily function is ‘limited a lot’.1 Post-COVID-19...

Abstract As we adapt to SARS-CoV-2, it has become apparent that the acute illness is not the only threat from this virus. Long COVID has emerged as a potentially disabling condition with multiple varied symptoms. We propose that querying patients about their sleep may allow for the assessment...

Abstract Patients suffering from Long-COVID syndrome experience a variety of different symptoms on a physical, but also on a psychological and social level. Previous psychiatric conditions such as depression and anxiety have been identified as separate risk factors for developing Long-COVID...

This has been mentioned elsewhere on the forum previously but is worth a thread of it's own. Additional 'interesting' info from the document. "Acknowledgements Dr James N. Baraniuk would like to gratefully acknowledge Dr Craig N. Sawchuk and Dr Dedra Buchwald, previous contributors to this...

Last reviewed: 10 Feb 2023, Last updated: 19 Jan 2022 Summary Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can be distinguished from medical and psychiatric conditions in the differential diagnosis of fatigue by the presence of debilitating fatigue for more than 6 months...

Abstract Myalgic encephalitis/chronic fatigue syndrome, an intractable disease characterized by profound fatigue, sleep disturbance, cognitive impairment, and orthostatic intolerance, among other features, often occurs after infectious episodes. Patients experience various types of chronic...

ONS Covid infection survey paused after 3 years, leaving no official method for tracking virus "The [UK] government’s Covid infection survey – regarded worldwide as the “gold standard” for surveillance of the virus – is being paused for several months. The weekly survey published by the Office...

How the brain senses a flu infection — and orders the body to rest "A case of influenza can make even the toughest people take to their beds and lose their appetites. Now, scientists have identified neurons in mice that notify the brain of a flu infection, triggering decreases in movement...

Abstract Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by neurons3,4; yet, the responding neural...

Background: Post-COVID-19 exercise intolerance is poorly understood. Cardiopulmonary exercise testing (CPET) can identify the underlying exercise limitations. Objectives: To evaluate the source and magnitude of exercise intolerance in post-COVID-19 subjects. Methods: Cohort study assessing...

Abstract Learning objectives: • Develop and implement treatment plans for children and adolescents with functional neurological disorder (FND)• Outline a plan to increase awareness and standardize the care for patients with FND using evidence-based interventions. Abstract: Functional...

The special committee on the COVID-19 pandemic organises two workshops to discuss the state of play of EU’s crisis preparedness and response, and developments related to “long COVID”. When: Wednesday, 8 March 2023, 15.00 - 17.00 Where: European Parliament in Brussels, Spinelli building, room...

Abstract Objective To synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic. Design Systematic review. Data sources Medline, PsycINFO, CINAHL, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang, medRxiv, and Open Science...

"Rugby had defined Burton's life, but she was soon given a "new perspective". Burton, who made her England debut aged 18, says she first noticed a change in her behaviour when she started to feel "really down" and had no energy." "She remembers being put on anti-depressants because "the first...

Abstract Purpose Critical torque (CT) and work done above it (W′) are key predictors of exercise performance associated with neuromuscular fatigue. The aim of the present study was to understand the role of the metabolic cost of exercise in determining exercise tolerance, CT and W′ and the...

Highlights FD mice and patients show intolerance to aerobic activity and lactate accumulation A metabolic remodeling occurs in FD muscle with a glycolytic switch miR-17 mediated HIF-1 upregulation is responsible for the Warburg effect in FD muscle Exercise testing, blood lactate, and miR-17 are...

Relative energy deficiency in sports (RED-S): elucidation of endocrine changes affecting the health of males and females, 2020, Dipla et al "The purpose of this review is to present a different perspective of the relative energy deficiency syndrome, to improve understanding of associated...