Search results

From Turkey. One session a week for 4 weeks. Truly miraculous.

Dave Tuller said: Yes. The amazing thing is that the Cochrane Board reportedly seemed to think that their actions in December would reduce the difficulties the Larun et al review is causing them.

Yes, the main differences with menstrual phase were headache and migraine. If someone has a migraine bad enough to have to rest in a quiet room, as well as period pain, they are probably reporting that their fatigue level is a bit worse too. I reckon it wouldn't take much more than that to...

There's some more discussion of this lack of a relationship between doing the GET sessions and doing better here: Graded exercise therapy compared to activity management for paediatric [CFS/ME]: pragmatic randomized controlled trial, 2024, Gaunt, Crawley et al.

I think it could potentially be scientifically ok if they treat everyone, and in an independent blinded analysis, determine the status of each participant with respect to those two biomarkers. And then see if the 'responders' match up with the presence of their biomarkers. The study won't...

Yes, she definitely was being paid by Cochrane at some point, but also not being paid at others. Perhaps she was being paid for some part of 2024? If she was, that may have contributed to her belief that Cochrane was supporting the new review process and everything was back on track.

My understanding is that, in this particular case, some of the people on the writing group were Cochrane staff, so they were being paid a salary and the review was part of their day job. When funding was pulled to Cochrane, some/all of these people may have lost their jobs. I don't know if the...

Now finally published: Graded exercise therapy compared to activity management for paediatric [CFS/ME]: pragmatic randomized controlled trial, 2024, Gaunt, Crawley et al.

Gosh. I'd say that MAGENTA has permanently wrecked any prospect of pediatric trials of exercise therapies in ME/CFS. How fortunate that the wide sunlit plains of Long Covid and FND await.

I would really like to see an investigative journalist poke into the Magenta study and get some FOIs done. I think Crawley was running the study and leading clinical services for young people with ME/CFS. And then the study started in 2015 and finished in 2019, the data was there. I expect the...

Metabolites and lipids in lower abundance in ME/CFS than in the controls Non-exercise Metabolite ...p value ___________________ Hydroxyisocaproic acid ...0.0097 L-Ornithine ...0.018 Citramalate ...0.044

Metabolites and lipids in higher abundance in ME/CFS than in the controls Non-exercise Metabolite ...p value ___________________ Serine ...0.00094 7-Methylguanosine ...0.0062 Ureidopropionic acid ...0.0066 Aminoadipate ...0.0081 Homocysteic acid ...0.014 Creatinine ...0.017 Creatine ...0.022...

You have to open a table, Table 1, in Results to find out how many participants there were: Baseline sampling study Sedentary controls ....20 (9 female) ME/CFS ....45 (36 female) Post-Exercise sampling study Sedentary controls ....12 (2 female) ME/CFS ....15 (9 female) That pretty light on...

I'd say that maybe looks like double at each measurement stage compared to what we have seen in careful studies of post-infection fatigue syndrome/ME/CFS/LC. But, the data for everything to do with my statement there is all over the place and unreliable, not helped by vague definitions of...

The way Cochrane presents its reviews as advice has serious problems. Even good quality reviews will become outdated, so there needs to be a clear way of separating current reviews, that can be relied on for clinical decision-making, from the outdated reviews. An editorial note does not cut it...

:rofl: I suspect you are just playing with us, seeing who will bite. I think if you think that 'acting as if a hypothesis is true' isn't by definition harmful, when it comes to confidently telling someone why they are ill, you haven't been paying attention. Not to mention the damage it does to...

Yeah, it doesn't seem that qigong is anything particularly mysterious, it's just exercise e.g. Qigong is exercise; qigong applied to a patient group to improve symptoms is exercise therapy. There's no reason for Cochrane to say there have been no recent trials of exercise therapy.

Gosh, the petition is up to 14,977. Looks like we will crack 15,000 before February has hardly begun.

Thanks for the effort it took you to make that post @JemPD. I think it expressed things very well. @Medfeb, maybe JemPD's post is helpful?

There is the odd place where some of the history isn't quite right, but if the reporter was coming to the topic cold, they have done a heroic job in setting the story out. They obviously spoke to some informed people.