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I suspect that this paper will be cited quite a lot by proponents of the psychosomatic approach to ME/CFS because it seems to confirm their views. Therefore, I think it's worth having a closer look at it. This group has been publishing several papers based on the data of the Taiwanese health...

Here's an interesting quote from the discussion section of the paper: Abdominal pain is a cornerstone symptom for the IBS diagnosis. However, only 55% of the included ME/CFS patients reported abdominal pain during the last 10 days (Table 3), and of a relatively mild severity. Abdominal...

I was also wondering: if the selection criteria turned out to be more selective than initially thought, is it an option to have a second inclusion round? For example, new and more inclusive criteria could be created for a group with "suspected ME/CFS" who met the second but not the first round...

I haven't followed this closely so apologies if the DecodeME team has already tried this but a lot of ME/CFS patients might have gotten a different diagnosis (fibromyalgia, chronic lyme, POTS, hEDS, MCAS, depression, burnout, etc.). Perhaps it is an option to target those patient communities...

Ah yes, thanks @Dolphin the response rate might turn out to be significantly lower than 9000 then.

Trying to get an overview, so please correct my reasoning if I made errors. The target recruitment is: DNA samples of 25.000 ME/CFS patients. Currently around 9.000 patients have returned a spit. Not all of these will be useable samples but I suspect most of them will be (and patients where the...

So you're arguing that mild patients were in worse PEM during the test compared to the more severe ME/CFS patients? I doubt that would have such a big influence because for severe patients a trip to the doctor is also extremely taxing even if they don't have to do any physical activity to get...

If the endothelial dysfunction that they found was part of the core pathology of ME/CFS, I would expect a correlation with the SF-36 physical function.

They plan to recruit 66 patients of which 44 will be randomized to the Immunoadsorption group if I understand correctly. The other 22 will receive a sham intervention. So the idea is to plan patients but unfortunately it will not be possible to blind the nurses administrating the treatment...

Interesting findings but it was rather disappointing that the abnormalities did not correlate well with disease severity measures. This make it hard to argue that these abnormalities are part of the core pathology of ME/CFS.

So ME/CFS patients had higher levels of these microRNA's than healthy controls while FM patients had lower levels than healthy controls. Interesting result, just hope this wasn't due to the different selection process of the FM samples (they came from a different database).

It doesn't seem like they took the feedback/comments into account in the final report. I don't see any important changes. Has anyone spotted some? I don't think any of the comments we made (overview here) were taken into account or addressed, for example that they did not consider objective...

Looks like useful work. Hope he will continue to study ME/CFS.

Maybe it is good that they document this themselves otherwise people in the future wouldn't believe it was once this bad? Quote from the paper: "47% of HCPs responded they often use explanations based on the autonomic nervous system, whereas only 16% often talk about the immune system in their...

Supplementary figure gives the results of all health outcomes/diagnoses in one graph. It does look that CFS stands out a bit:

Bit disappointing that the authors included CFS in the mental diagnosis group:

Why does the title say "A critical investigation"? This seem like the exact opposite with the attempt to get a short section in trashy newspapers. The authors have even suggested a suitable title: "Bright, but allergic and neurotic?"

Agree 4 hours is a lot.

If they think a new paradigm is needed, why are they digging up the old one?