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Question for moderators: perhaps it would be good to have a subforum/topic that focuses on trial methodology so that these discussion threads are separated from the general health news?

@Brian Hughes

In short, I think research on absurd ideas might be useful to show flaws in study designs that psychology accepts as valid.

I thought this was interesting, thanks to Cyrus (EDIT: and Matthew Dalby) for highlighting this on Twitter. I'll try to explain briefly what this is about and why it is relevant to ME/CFS. Power posing is the idea that taking a posture associated with being powerful, result in a feeling of...

Fibromyalgia was assessed not by clinical examination but by a questionnaire (ACR survey criteria) where patients are said to have fibromyalgia if they score above a certain threshold. Regarding more males meeting FM criteria, the authors write: "Strikingly, we found a high percentage of men...

Here are more frustrating quotes from the article, including a reference to the PACE trial "The high symptom overlap between these syndromes and low diagnostic stability in individual patients can be argued to support core transdiagnostic aetiological factors underlying these disorders and...

Quotes: "Patients were included if they had debilitating symptoms suggested by either themselves or the referring clinician as being attributed to ticks." "The most common diagnoses made by our hospital were chronic fatigue syndrome (31%), migraines (28%) and fibromyalgia (21%)."

Apparently, there "no evidence that the bacterial complex that causes acute Lyme disease – Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) – exists in Australian ticks." So that makes it unlikely that these cases were due to Lyme disease (it could have been another tick-borne infection...

Objectives(s): To characterise the clinical profile, aetiology and treatment responsiveness of ‘Australian Lyme’, or Debilitating Symptom Complexes Attributed to Ticks. Methods: Single-centre retrospective case analysis of patients referred to the Infectious Diseases Unit at Austin Health – a...

1) The data reported by Dr. Dane Cook in this CDC call from 13 May 2021 is pretty interesting. He was able to analyze the results of exercise testing in the large Multi-Site Clinical Assessment of ME/CFS study (MCAM). 2) Previous meta-analyses have shown that ME/CFS patients have lower peak...

Interesting. There was recently an opinion piece in the New York Times that argued that long covid was psychosomatic because most patients did not show an antibody response to the coronavirus. The authors wrote: "Antibody testing has some level of false negatives, and antibody levels can wane...

I think this would be nearly impossible to do because in a control group there will also be patients where nothing happens and others where there is remission. So any interpretation of the pattern in the intervention group would need to take the pattern in the control group into account. In...

The headline should not be that patients are upset but that certain interest groups are sabotaging a NICE guideline that was three years in the making and that said that current treatments are not effective and potentially harmful.

I find it unfortunate that the debate shifts to whether ME is psychological or physical. Which ends in Chalder saying: "This kind of dualistic thinking – it’s either psychological or physical – is not particularly helpful..." The title and headline are also terribly: "Withdrawal of planned...

The article lists studies that reported altered metabolites in ME/CFS and fibromyalgia. It then argues that "induced pluripotent stem cells" (iPSCs) may be used as metabolic sensors for FM and ME/CFS. The authors write:

Looks like a really great article. There aren't many journalists who get so many of the issues right. Last year Chivers won the Royal Statistical Society "statistical excellence in journalism" award. He has previously written previously about the Lightning Process and ME. Thanks to John and...

She was talking about theoretical examples, not actual cases if I understood correctly.

There is also this document dated 22/07/04 which states: "There is no disease - you have a right to full health. This is a good news diagnosis. Carefully built up exercise can reverse the condition. Go for 100% recovery." Are there other things that are missing, and that should be uploaded?

On twitter, Chris Ponting clarified that the data included the rare and nonrare mutations of IDO2.

Is this the patient booklet that you mean or were there others? https://web.archive.org/web/20140811161130/http://www.fine-trial.net/downloads/Patient%20PR%20Manual%20ver9%20Apr05.pdf