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Summary based on quotes from the text: Based on metabolites tested, ME/CFS were divided into three groups (M1, M2, M3). There was relatively little overlap between the health controls (HC), ME-M1, and ME-M2 clusters, whereas the ME-M3 subset was positioned as a merger phenotype between the 3...

To clarify: the survey is full of frustrating or stupid questions but If I understand correctly, this is not because the current authors have designed them as such. They are studying these problematic questionnaires and want patients' reponse to it.

1 patient, 21 authors?

A "physiologically severe stressor" in "genetically susceptible people" is as unclear as can be. The gist of the theory revolves around the hypothalamic paraventricular nucleus (PVN). The authors describe it as follows: The author has previously written about this, this paper seems to add...

The following info about the study is given on the second page at the link provided above What is this study about? The current study will test different questionnaires (questionnaires are also sometimes called surveys or scales). Questionnaires are a set of standardized questions. We are...

Here's an attempt from a noob when it comes to genetic studies: Because of linkage disequilibrium, it is difficult for the researchers to know what genes the association signals point to. So the authors discuss what the strongest signals their study found, could mean. One of the clearest...

The databank also has a phenotype called: "Phenotype:41202#G933#G93.3 Postviral fatigue syndrome" but it had only 43 cases, so unsurprisingly, nothing was found. data here: https://azphewas.com/phenotypeView/5ff51c28-7a5e-4337-88d5-3649e55f605c/f071f00b-d4c1-4fbd-bcdc-9228f2c39cee/glr

The hypothesis paper says: "Outbreaks or epidemics of a noncontagious disease raise the possibility that genetic predisposition to ME/CFS is very common in the population and that the disease has low penetrance only because the initiating triggers are multifactorial, and those pathogenic...

I'm not sure what the IDO trap hypothesis predicts. I remember that Phair came to IDO2 because he thought it had to be a common mutation because such a large proportion of the population was affected in ME epidemics. Does anyone know how relevant this data on rare mutations from the biobank is...

Interesting. Thanks to the person who made the DecodeME thread. I think the data for CFS are visible here: https://azphewas.com/phenotypeView/5ff51c28-7a5e-4337-88d5-3649e55f605c/870fa4a7-d96e-43dd-b35d-de8a49a6941c/glr There were 1232 cases and 195 965 controls. None of the rare genes tested...

Agree, how come no data on response rate was given? They say this was part of the SchoolCoviDD19 study. The trial registration seems to say: "blood were collected from each individual during visits at each participating school between May 25th and June 30th, 2020." So if blood was drawn at...

Symptoms were scored on a scale going from “not at all” “a little bit” “quite” “severe” “very severe”. The authors gave the first category a dummy code of 0 and all the other categories a code of 1 and then compared the two, which is a bit strange. I've quickly looked at fisher exact tests if...

The authors conducted antibody testing for the coronavirus in 1560 students with a median age of 15 years. There was no statistical difference comparing the reported symptoms between, 188 (12%) seropositive students and 1365 (88%) seronegative students. The study is mentioned in this article...

Abstract Background Post-COVID19 complications such as pediatric inflammatory multisystem syndrome (PIMS) and Long-COVID19 move increasingly into focus, potentially causing more harm in this age group than the acute infection. To better understand the symptoms of long-COVID19 in adolescents and...

Their main argument seems to be that so many patients with long covid have negative antibody tests. They refer for example to the survey by Hannah Davis and colleagues were more than 2000 respondents said to have had an antibody test (IgG, IgM, or both) but only 18.2% had positive results...

The authors seem to have figured it all out. They think they know the cause (psychological distress) and treatment (rehabilitation). They write: "if we understand this form of long Covid as a complex chronic illness, a biopharmaceutical solution is unlikely, and there may be no single cure...

Agree, see: This has been shared eagerly in Dutch Facebookgroup, with patients thinking that NICE requested this urgently. Not very happy with this approach.

Looks like pseudoscience, not helpful. Agree

We have been working on a comprehensive overview of funding sources, biobanks, and networks for scientists interested in studying ME/CFS. https://europeanmecoalition.com/resources-for-researchers/ I don't think many know that NIH funding is open to researchers in Europe and that US researchers...

Quote from the paper: "Prior to attending the three-day LP course, the participants had a telephone conversation with the course instructor to clarify any issues they might have and to allow the instructor to assess whether they were sufficiently motivated to proceed with the intervention. The...