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Maybe the right time is to measure every day for a week while the patient is doing a little too much. Not enough to cause a serious crash but enough to be a little too much.

A study by Morten and his Polish collaborators found a decrease in central energy metabolism in patients with ME/CFS when comparing pre and post exercise program timepoints. There was no control group so this was not published. This study of exercise for long covid also seems to be reporting...

Is this saying that oxygen-dependent energy production decreased?

I've been going swimming almost every day lately and there is a trend of finding it increasingly difficult over time. I keep having to reduce the time and intensity and have to spend more time horizontally during the rest of the day. This is similar to other periods in my life so it's probably...

I believe that something like LP has a high risk of long term harm because it attempts to persuade patients to believe in something that is not real. In the short term this might lead to some positive feelings but in the long term it cannot be good. A person that believes they can and should...

As far as I know, there's still no evidence somatization is actually a thing. They can't even define it clearly enough to allow falsification of the concept. Some people just really want to roleplay a thing where they explain to patients that their reality is false and that they're emotionally...

@DMissa are you interested in hearing some ideas on how to investigate PEM and ME/CFS?

They defined it as tendency to avoid unwanted experiences.

Something like heat shock proteins being dysregulated might explain the poor stress and exertion tolerance of patients (they don't just protect cells against heat shock but against many types of stressors).

Not liking the positive spin in the abstract. The questionnaire results don't look impressive and are uninterpretable due to lack of controls. I suppose the purpose of the study is to show LDN isn't causing any obvious serious harm so that a proper clinical trial becomes easier to get funding for.

Illness doesn't begin at diagnosis. It's likely that all these people are already sick with whatever illness they have, even if it takes another few years before they're diagnosed. In that time, the illness could destroy their life and cause "life events". By the time people make contact with...

HSF2 is required to maintain cell-cell adhesion HSF2 deficiency leads to downregulation of cadherin superfamily genes Impaired cell-cell adhesion sensitizes cells to prolonged proteotoxic stress Cadherin-mediated cell-cell adhesion is a survival determinant upon proteotoxicity...

Blog by a person who tracks her health data over time. Observations Summary: Fluctuations in temperature, resting heart rate, inverted HRV, and activity levels are all tightly correlated & periodic with my menstrual cycle. Counterintuitively, I seem to have more energy when resting HR is...

Hanson et al did not report which type of cadherin was elevated in ME/CFS, if any. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931008/ If one type of cadherin stood out from the others, it would hint which type of tissue was involved. VE-cadherin would suggest a vascular problem and whatever...

Adhesion molecules are cell surface proteins that mediate the interaction between cells, or between cells and the extracellular matrix (ECM). There are four families of adhesion molecules: immunoglobulin-like adhesion molecules, integrins, cadherins and selectins. ME/CFS was associated with...

Something that has also happened to me is eating a lighter dinner than usual, and the next morning going out for a walk after the usual breakfeast and ending up having what felt like a mild episode of hypoglycemia.

When reading papers like this, I always have to think back to when I was getting therapy for "school refusal" (actually crippling fatigue, but that wasn't allowed to be real, it had to be a psychological problem) and I treated therapy as some sort of process where I had to go along with whatever...

A bit more information on what the WAVE3 gene does in the cell besides having something to do with mitochondria. It's part of a protein family that is also involved in cell movement, which involves restructuring of the cytoskeleton. I'm not entirely sure but believe that cell adhesion and...

Increased expression of this protein seems hard to interpret because it's involved in so many different things. But that the NIH is doing a mitochondrial study led by a cancer researcher suggests that they might be thinking that the interaction between WAVE3 and mitochondria is the most...

My understanding is that the link to mitochondria is autophagy (degradation of damaged cellular components) and maybe also organization of the mitochondrial network. It also has various other roles. But this is a complicated topic and I may be misunderstanding. I'll have to read more. It's...