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Processes this gene is involved in involved_in actin cytoskeleton organization IBA PubMed involved_in actin filament polymerization TAS PubMed involved_in cytoskeleton organization IMP PubMed involved_in lamellipodium assembly IEA involved_in modification of postsynaptic actin cytoskeleton...

The pre-publication thread has been merged with the thread on the paper. Link to paper's abstract here...

I also doubt that PEM defined as pattern of symptoms worsening with a delay after exertion is unique. But it could be a situation where there are different kinds of PEM that are not being distinguished due to lack of research. What is seen in the 2-day CPET may be much more specific, and there...

I had a pulse pressure of 20 at times. I interpreted it as likely being due to low blood volume (mimicking the effects of major blood loss). It varied a lot over time so seems to make heart disease as cause of it unlikely. Faulty regulation of blood volume and water content of the body seemed to...

I should mention that I can have PEM before sleeping too, but my typical presentation is next day PEM after sleep. I don't know enough about the topic to make specific predictions, if that's even possible at the level of knowledge we have. I also remembered that there was this recent paper...

It's difficult to know what really happened. It's possible to emphasize different symptoms and aspects in the same disease. That Ramsay emphasized these doesn't mean the patients didn't have the symptoms that are emphasized today. Maybe at the time physicians were trained to describe disease in...

I took manganese for a while after finding out I may be deficient as it seemed like potential cause for some of my symptoms. My impression is that it didn't do anything. That doesn't mean there's no merit to the idea. If there is a deficit, it might require a different approach or dosing or...

This idea has come up before and I thought it would be interesting to write down some of my thoughts on this. Housekeeing processes have a role in keeping cells healthy by doing things such as maintaining structural integrity and degrading and recycling intracellular components (like...

A problem with the microtubule network could lead to the axons of neurons dying. This is what happens in some neurological diseases. The effect depends on which neurons are affected. I suspect it would be fairly obvious if this was occurring in ME/CFS. Maybe the resulting problem isn't serious...

In my family there was 1 case of cancer in 4 generations and no autoimmune disease. Nothing major at least. I think I may have some psoriasis but it's so mild that it's hard to tell. My mother might have some autoimmune thing affecting her fingers but she has refused to get it diagnosed and it...

@Jonathan Edwards You mentioned something about solid phase information and how this could explain why the mechanism in ME has been so hard to observe. Can you elaborate on this? Edited: I was wrong to believe that this gene had been linked to neurological diseases.

I've known for many years that I have a tendency to experience reactive hypoglycemia. It was much more noticable in my early 20s. It's different because it tends to occur 2+ hours after meals and causes symptoms of hypoglycemia, which includes hunger and things such as sweating, tremor in the...

What is the formal name for this? Is i postprandial hypoglycaemia or some sort of carbohydrate intolerance?

I found some meat in the freezer and decided to have a mainly meat based dinner to see what would happen. A few boiled carrots, boiled meat, and a raw tomato. Two hours later, I have not felt any uncomfortable hunger and my digestive system feels good. Energy is holding steady.

Would you agree with the following idea? If you can reach a state of acceptance of your illness and the limitations, then you can better work within those limitations and achieve more than before because you're now able to set realistic goals, instead of setting goals that don't respect the...

I had actually wanted to cook some meat today but there was a long queue in front of the butcher shop. As we all know standing still in the heat is not a great idea for us, so I just didn't bother. Tourist season has fully begun now and there seem to be even more than usual. PS: Carnitine...

So you believe it's likely that in my or our case this is just a signal for needing more nutrient rich food? I've been eating a little too much bread lately and neglecting meat and fruit intake (due to recovering from a muscle biopsy and simply not having the energy to cook properly). That's...

Nitric oxide donors. Various drugs used to treat angina pectoris.

The best meals for preventing this seem to be rich in meat and cooked vegetables. Maybe it has something to do with needing more amino acids than normal, as suggested by research finding lower levels of anaplerotic amino acids in ME/CFS?

Despite an apparently normal food intake, I sometimes feel like I'm starving. I can also become hungry again despite still having a full stomach from the last meal. What could be causing this?