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Beautifully put. And, for much the same reason, in a brief document aiming to educate doctors, it makes no sense to present as fact ideas about the cause or treatment of ME/CFS, when those ideas don't have a significantly more solid evidence base than the BPS ideas we are asking people to ignore.

There is some good material in there - descriptions of PEM, and differentiating it from post-exertional fatigue for example. A few of the problems I noted above in the last version aren't in this version. I don't think this resource needs to suggest that FND and somatic symptom disorder are...

I've just started new version. I think my comments above still mostly apply. Some of the reading list seems oddly chosen. For example, here is the first paragraph of explanation for the answer to the first question: "ME/CFS is a chronic, multi-system disease with different patterns of onset...

Another consideration is that typically there is someone benefiting financially from these therapies. If you are, for example, a seller of aromatic oils as part of a MLM scheme, it would be in your interest to report that aromatherapy is fantastic for Long Covid. That reporting might be done...

There's a pay wall. "Fear avoidance model in chronic pain" - a diagram from the paper I suppose there might be the odd person who thinks jejunal feeding is a good time, or at least worth the secondary benefits that accrue, or who is unnecessarily afraid of eating. But off-setting the harm...

That's an interesting blog Jenny, my first time (as far as I know) reading a ChatGPT product. Although yesterday a major media outlet in my country announced it was slashing its staff numbers, so perhaps I have read a lot more ChatGPT than I am aware of.

Also at that seeking alpha site: Axcella CFO to depart among 85% staff cut in program reprioritization, restructuring Dec 15 2022 Axcella Therapeutics (NASDAQ:AXLA) said it is exploring strategic alternatives and reducing its workforce by 85% amid a reprioritization of its programs due to...

More from that Type I and Type III paper linked in the last post: There are lots of issues important to be aware of when studying the cells. How close together cells and whether they are polarised are might influence whether the ISG's, the interferon stimulated genes, get turned on by...

This recent paper is very readable, giving background on IFN; there's quite a few interesting points for our purposes: Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces From what I can see, Type III IFNs can be produced by many cells, but the receptors to...

Re female predominance Monocytes are the main source of STING-mediated IFN-a production, 2022 Summary Background Type I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infec- tion, in response to Toll-like receptor 7 (TLR7) stimulation and is more...

Ha. We had a duplicate thread on this, merged now. I got to be a bit excited about it all over again. At least I was consistent.

Andreas Zollner ∗ Robert Koch ∗ Almina Jukic Alexandra Pfister Moritz Meyer Annika Rössler Janine Kimpel Timon E. Adolph Herbert Tilg § Seems like there has been some good research coming out of Austria on Long Covid. I'm not sure to what extent the researchers overlap. In the discussion...

Here's the Table 2 information presented in graphical form. Sorry, I'm making a dog's breakfast of this commentary. So, it sounds like people might have had established IBD before infection, rather than as a consequence of the Covid infection. It was noted that over half were in remission at...

Austrian paper. The indications that persistence of pathogenic material might be causing ME/CFS (including post-Covid-19 ME/CFS and post-Ebola ME/CFS) keep coming. It's not clear to me yet (just part the way though the paper so far) how many of the patients who were attending this IBD...

So things they are working on now: 1. Checking if the two healthy control outliers are producing IFNa in their blood cells which might be confounding the results 2. (39 minute mark) Checking if the pathways that are supposed to turn off the IFNa feedback loop e.g. SOCS3 are actually doing that...

Thanks Ben H, and for your tweets. Yeah, sorry if that wasn't clear, if I'm understanding you correctly, that was what I meant to convey (and it is clear in the video) - In the anti-viral state, the neighbouring cells are induced to turn on the Itaconate shut and produce their own IFNa.

So, you might think that it should be possible to find more IFNa in the blood of people with ME/CFS. But yes, I don't think you are kinda dumb belbyr, the preliminary results aren't very convincing at all. The median is higher in the ME/CFS samples, but there is an enormous amount of overlap...

So, the guts of it is that there is an infection, the presence of the pathogen is recognised by toll-like receptors in the cell, causing the infected cells to sending out signals. There are inflammatory molecules e.g. TNF-a that increase the permeability of the vasculature so that immune system...

I was doing a bit of work on something else, and came across this paper: I won't make a separate thread for it because it's pain, not ME/CFS related, but it's a terrific example of how the problems of poorly conceived measures are then compounded by data analysis techniques that take the data...

Yes. Q. 3 Do you feel exhausted? Q. 5 Do you feel energetic? (measured in the inverse) These questions are essentially asking the same thing. But one is physical and one affective. It makes no sense whatsoever. As for Q. 12. Do you feel reluctant? (which is in the physical category, of...