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One contributing factor that I don't think we have mentioned is hypersomnia. If someone is asleep for, for example, 20 hours of the day, and not very alert for the remaining 4 hours, it is physically difficult for their carer to get enough food and water into them during that window. It also...

Things are hazy now, but I think that there were some FMD measurements done as part of the 2xCPET study that Lyn Hodges and her team did (and that I participated in) - before and after the exercise. I don't recall seeing that part of the study being published. It might be worth checking Lyn...

you mean 'that can't get corrected?' There is research going on at the university my son goes to. He had to practice peer reviewing the thesis draft of another student in the biology department, and it just so happened that he got a thesis reporting the results of work looking at the...

What are you thinking @SNT Gatchaman? (said in a tone of enquiry, not sarcasm :)) It sounds as though the pain in PAD occurs during exercise and improves with rest. I get leg aching and burning when lying in bed in the evening rather than during walking. Are you thinking the problem of...

Potential issues in ME/CFS that may cause weight loss (have I missed any?) Difficulties procuring food and preparing (appetising) meals Anorexia - lack of appetite Food intolerances or perception of food intolerances Difficulties in eating/chewing (perhaps due to a general lack of energy) Gut...

That's a good article. It mentions Worobey - the arguments against the market origin include the fact that environmental swabs were positive from the plant and seafood sections of the market, not the meat section (although I guess the meat section may have been disinfected) and that there were...

Thanks, I did assume it was something like that, but having a Dept of Energy in charge of nuclear weapons just adds weirdness. Perhaps it's politically more acceptable for the Energy Department to say this than the CIA.

I'm not sure why the US Energy Department's opinion on the origin of covid-19 carries much more weight than 'Hutan's opinion on the origin of covid-19'. What's the connection between the origin of a virus in China and a department that presumably is responsible for keeping the lights on in the...

Some posts about specific people currently experiencing eating difficulties have been moved to United Kingdom: Cases of people with ME/CFS with severe feeding problems, in the media There is some content in those posts relevant to the wider questions being discussed here.

What do we know?

Re Speight and Weir: Surely that's an understandable approach though, if you are trying to get specific investigations into physical problems, or when faced with people who don't believe in pandering to a patient with what they believe is a problem that could be fixed if the patient just...

I agree. I'm not sure that there is necessarily a change in appetite. When I got post-prandial pain, it had no effect on my appetite. I remember reading posts from people with ME/CFS who wanted to eat, but reported suffering very badly when they did. But, presumably things can affect...

Believing that you can't or shouldn't eat, when there is no functional problem seems to fit the definition of a psychosis. It is a loaded word, so yes, probably best avoided, but I did find the medication-induced psychosis a helpful analogy. I've probably missed this, but what are Drs Speight...

It would be good to hear why you favour this theory. Do you want a thread started to discuss it?

Yes, one of my synapses was pinged about Serpina5 also. Googling some of those on the list, there are interesting possibilities. edit - only problem is, in this study, Serpina5 in LC was 4 times the mean of the healthy controls and acute /covid combined (not sure why the authors did that) i.e...

I'm trying to understand. I understand the point that giving someone who is unwilling to eat because of a medication-induced psychosis psychotherapy to examine their childhood traumas is unhelpful. There's a neurological cause rather than a psychological one; the strategy should be 'keep the...

Listing all of the 119 proteins found to be different from Supplementary Table 1, so the search engine will pick them up: (Again, I'm so disappointed that the comparator isn't post-Covid healthy people. This could have been a treasure-trove of clues.)

Figure 2 does possibly show that. I can't quite understand the charts, they say that the green shaded area is the 5-95% range for healthy controls, but for most charts the healthy controls are mostly just represented by a single line (the mean?) with the Long Covid individual points plotted...

I note that cd69, one of the immune cell receptors found to be upregulated in the Long Covid cohort compared to the healthy controls, is one of the proteins found to be possibly affected by long term freezing*. The healthy control serum had been stored frozen for some time. * Impact of...

Re hope, some earlier discussion back here: