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Just adding - MEPedia on Peter C. Rowe. Looks a though he has been interested in pelvic congestion syndrome for a while.

The full list of authors probably sheds some light on that: Steven J Smith1, Michael Sichlau1, Luke E Sewall1, B Holly Smith2, Brenda Chen3, Neal Khurana4, Peter C Rowe5 Peter Rowe, seems to be the one we know - he's keen on the hypermobility - ME/CFS link and neck surgery too I think. The...

That they need to start learning how to be qigong masters, because the practice produces outcomes that are as good as CBT and it sounds more fun, with its pressure sensing glove and all?

Here's an explanation of how TFEB becomes activated (TFEBa) so it can then potentially go on to turn on the itaconate shunt): (Basically, the TFEB molecule sits in the cytosol, inactive. Then, when there is some adverse condition e.g. starvation , infection, ROS, ER stress or mitochondrial...

Itaconate produced by mitochondria can be moved into vacuoles containing pathogen bacteria where it inhibits pathogen proliferation. Most of the authors of this article are based in Freiburg, Germany. I thought the mention of iNOS as an inhibitor of itaconate synthesis was interesting...

Interesting paper, confirming the itaconate shunt as a means of controlling bacteria in macrophages and demonstrating that measuring levels of itaconate in cells is straight-forward.

This survey tells us nothing. With a response rate of 7%, the self-selection bias will be through the roof. Add to that two other problems with the sample: the high likelihood of mis-diagnosis of the PCS condition, either by doctors or by self-diagnosis, and of the various co-morbidities...

I actually thought that response by Walensky was ok. 'Manifestation' might not be the best word, although it is reasonably accurate, but it is true that there are a range of health impacts following Covid-19. I think it is useful to be very clear that 'Long Covid' covers a range of symptoms...

agreed Yes, I edited my post about the 'health problems' reporting. I see that there were a lot of detailed questions about sick leave in the survey. It would have been good to see some of the results from those in the paper. 'Full-time sick leave' seems to refer to taking a whole day/week...

[See my post below - I have understood full time and part time sick leave differently from what was intended - full time sick leave is taking a whole day off, not being on sick leave all of the time since the Covid-19 test.] I think monitoring of sick leave is a good thing for studies to do, as...

I interpreted 'self-reported health problems with new onset between the test date and until 6-12 months after' as a new health problem starting after the Covid-19 test date (and probably having an ongoing impact), rather than as symptoms of the acute infection and a few weeks after. But I see...

Worth noting the samples aren't of the same type of people - most of those differences are highly significant. That's a really big difference in new onset of physical exhaustion (defined as a health condition) (risk difference 40% - 45.5% in the test-positive sample and 7.3% in the...

It's a great number of respondents, but self-selection looks to be a major problem.

I think you are right @Andy, but I wouldn't want anyone to feel shame for feeling shame. I think there are quite a lot of factors, including the exposure to gaslighting (or instead to good information) and the extent of reliance on others for practical support. I think everyone is concerned...

So yeah, where I was heading with the risk difference was that, say for depression, it looks as though having a Covid-19 infection is associated with an additional 1 person in one hundred getting a diagnosis of depression between 6 and 12 months after infection. I'm not sure that that is enough...

This risk difference thing Statistical notes for clinical researchers: Risk difference, risk ratio, and odds ratio So fatigue % at 6-12 months in Covid positive was 11.1% and in Covid negative was 3.1%. Then you just subtract one from the other, giving a risk difference of fatigue of 8%...

Something like this: The influence of posture duration on hand tremor during tasks with attention-distraction in persons with Parkinson’s disease In that case, drawing attention to the tremor can reduce or even stop it, and stress can increase tremor. I don't think it should be surprising...

It's hard to tell from the abstract exactly where this paper lands. I think it's good that they objectively assessed tremor in the three groups and assessed subjective reports of how bad people thought there tremor was. I think it's good that the researchers reported that people with FND were...

Most of the research about ME/CFS using animals has been egregiously bad - completely unlikely to generate any useful information, torturing the animals and then concluding things that could not fairly be concluded, leaving the ME/CFS research field muddier. It leaves me appalled at the humans...

Super