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Thank you for that detailed response @hibiscuswahine. Clearly where you have practised is not like the UK where, reportedly, functional disorders are one of the commonest reasons for people to see a neurologist. It's very good to hear that functional disorder diagnoses are relatively rare in...

The spike protein triggers neuroinflammation The researchers tried applying the protein directly to the neutrons - that didn't seem to injure the neurons or affect synaptic density. In the early stage after injection of the spike protein into the brain didn't change the number or shape of...

I suppose potentially it might. The researchers tried a lower dose of the protein (10-fold smaller), and it didn't affect memory at all, so dose seems important. I haven't looked at and thought about what dose they used, but it's possible that the dosage used in this study in mice is not a...

@hibiscuswahine, I appreciate you telling us about your experience. I certainly don't have first hand experience of people diagnosed with functional motor disorders. What is it about them that makes certainty that the problem doesn't have a physical cause warranted? From what I have read...

Brazilian team Introduction There does seem to be evidence that virus particles do get into the brain, and for some time after the acute infection. The paper did not say in the abstract or Introduction, but I'm assuming TLRs is Toll-like receptors. So, they are suggesting there is evidence...

I do forget. These days, given the amount of sarcastic comments I am making, it might be easier to have a [not sarcasm] note when that happens.* *[sarcasm]

Note the truncated y axis, making the change in fatigue scores (potentially 0 to 60) look more impressive than it is. Participants had to have a score above 24 to participate in this fatigue reduction trial. Note also the use of 'standard error' error bars. Most studies use a 95% confidence...

and then there's Eurythmy: "O-EM-L-EI-B-D (the so-called cancer series)". Haven't these cancer-survivors been through enough without that? I hate to think what the "clenching-spreading, striding" stuff is. It would be really hard to make stuff up that is more preposterous than this to fix...

I've tried again, but it still does my head in a bit. So, for the whole sample, the controls had a mean vessel density in the SVP of 30.1. The paper makes a big thing of patients with the symptom of chronic fatigue (CF). This group (with fatigue as one of the symptoms of their post-covid...

There's some relevant discussion here: Snow Leopard's cornucopia of wonder! Including this paper: Beyond the Matrix: The Many Non-ECM Ligands for Integrins Some pathogens can disrupt the VEGF mechanisms e.g. increasing vascular permeability for a given level of VEGF The impact of a certain...

:rofl: Perhaps these conversion disorder patients just need to feel involved in something worthwhile in order to recover? Perhaps the title was inspiring for them? Perhaps they thrive on being patronised? ;) Re VEGF: The mean from a sample of VEGF was 29.6 with standard deviation of 18.8...

:confused:

Exercise intolerance and ME/CFS Rather than high levels, there are some papers suggesting that low levels of VEGF might be relevant to ME/CFS. ..effect of VEGF gene inactivation ... on muscle enzyme activity, capillary supply & endurance exercise, 2020, Breen et al In mice. That thread has...

Fibromyalgia CGRP, VEGF, and Clinical Manifestations in Women with Fibromyalgia, 2022, Rus et al. That study looked at levels of VEGF in women with fibromyalgia; they did not find any differences from healthy controls. Conversion disorder/motor FND Assessment of cytokines, microRNA and patient...

Ebola Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes 2023 Gao et al Ebola virus particles have been found to stimulate pericytes to secrete VEGF, causing a weaker blood-retinal barrier. They give examples of viruses affecting...

So, if a cell doesn't have enough oxygen, all other things being equal, it sends a signal that releases VEGF-A. VEGF-A binds to endothelial cells, triggering angiogenesis, the development of new blood vessels. We have this paper related to this: The Emerging Role of Pericyte-Derived...

By popular demand, a thread on VEGF, Vascular Endothelial Growth Factor. As the name suggests, it's involved in the growth of blood vessels, e.g. after wounding or hypoxia.

No need to apologise, you don't. Besides, people posting is what keeps the forum alive. I'll make a thread to discuss it, if we don't have one. Here: VEGF - Vascular Endothelial Growth Factor

I don't understand @duncan, what is the link?

That study looks at acute Covid-19. They didn't find any difference between hospitalised patients and controls with respect to vessel density.