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But, can't your hand actually reach to the bottom of the pocket? The diagonal line across is attaching the pocket to outside facing denim. Unlike Cochrane, I don't think there is anything that isn't serving a useful purpose there. (The little pocket on the outside is arguable.) (@CRG In this...

https://mdpi.altmetric.com/details/142429311 The countries that have people tweeting about the study include Peru, Japan, El Salvador and Croatia. The attention rating is "in the top 5% of all research outputs scored by Altimetric". On MCAD, many of the symptoms sound familiar. However, MCAD...

Yeah, good comments. A bigger sample might have found metabolites that are significantly different at baseline? Maybe the ME/CFS averages are being confounded by people in the sample who don't have ME/CFS? A combination of those two things? I don't know. Yes, someone give Maureen and her...

Yes. Only 619 sailors out of the 1767 sailors on the aircraft carrier completed at least one followup? Only 193 sailors filled out the HAD depression survey at 12 months. Only 198 sailors answered the questions about Long Covid at 12 months (Table 3). That's a pretty pathetic response...

:) Well, that prompted a google search that contributes to my search history surely defying any categorisation. I still have no idea what extra bit of material Jonathan means. Regardless, I don't think it is a perfect analogy, because Cochrane does continue to be visible, and in fact highly...

Yes. Wasn't this supposed to be a shining example of patient engagement? Surely even Cochrane itself has to recognise it has utterly failed with that? In fact, it has utterly failed generally. The harm (caused by the Cochrane stamp of authority for exercise treatments for ME/CFS)...

From Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases, 2019 I read that as A range of metabolites can be toxic if they accumulate. They form esters with CoA, (CoA being a molecule important in the Citric acid cycle i.e. important for producing ATP). (e.g. for benzoate...

I assume the lower levels of these metabolites after exercise in the ME/CFS samples compared to the heathy controls is a key finding. See chart B above- the red dots. I just hope the difference isn't due to the higher BMI of the healthy controls. I've got to the end and I see the authors...

There was the recent fibromyalgia versus ME/CFS and healthy control difference in a study, but in that case the fibromyalgia samples came from a different source, and it seemed likely that some differences arising from storage probably accounted for the difference. There doesn't seem to be any...

I've had the same thought. If there is a lack of energy with processes working slowly, perhaps the kidney and the rest of the body just hasn't had time to get the metabolites out to the urine in the people with ME/CFS? Another tweak on a replication would be to track changes in urine over a...

I'm half way through reading the paper. I've got to say, this is really well written. It's clear, and possible concerns (like issues with changes of concentration of the urine) are anticipated and answered. Just reading the Introduction, I feel as if the study was in safe hands. If anyone...

They include hypermobile EDS in the group of conditions they are talking about. Unfortunately, they just refer in vague terms to the incidence of severe Long Covid in people with established EDS. They don't tell us how they came to have had "numerous contacts with people suffering from long...

At that symposium: Paul Garner presenting "How to recover from Long Covid" This n=1 story about recovery from Long Covid, a collection of health conditions where natural recovery is the norm rather than the exception, from a Professor of Evidence based-medicine.

Forthcoming (March) symposium on Long Covid, featuring Garner and White. Perhaps the BPS crowd got concerned that that the Long Covid space was being occupied by the biomedicalists (see post above). Link: Paul Garner on Long Covid and ME/CFS - BMJ articles and other media. Edit - we now have...

This paper has been cited as providing evidence of low cortisol in people with Long Covid. I had a closer look. Summary: just go to the last chart. The data don't support the idea of low cortisol in people with Long Covid. This paper had several samples, but the primary one and the one that...

Yeah, maybe, but there are references elsewhere to high levels of short chain fatty acids in the gut being a problem. One possible cause is malabsorption. If that's the case, then both the low levels and high levels of SCFAs in faeces could indicate low levels in the gut epithelium, with the...

I'm finding it a bit confusing. On the one hand, low short-chain fatty acids seems to be a problem and associated with post-infectious disorders, on the other, as here, higher levels of short-chain fatty acids are a problem. Just what is being measured for SCFA's is not always clear.

Livinglighter, do you have evidence that butyrate that you eat actually gets to the intestines? Genuine question, I haven't looked. Wouldn't it be better/cheaper to eat more fibre, to grow the bacteria populations that produce it in the intestines?

Butter is high in butyrates, and while having a substantial intake of butter is a delicious experiment, I think I can safely say it doesn't fix ME/CFS. From what I read, the butyrate molecules don't necessarily make it past the stomach. But, eating lots of fibre does feed the bacteria that make...

These studies are all blurring into one another. Hard to tell from that brief abstract, but it looks as though these authors made the basic error of assuming Long Covid is one thing. If you don't separate the different sorts of Covid-19 sequelae (e.g. post-ventilator damage, heart damage etc)...