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I'm just wondering if we could get views from @Jonathan Edwards @Snow Leopard --- on this publication. Thanks in advance.

From memory - I noticed James Baraniuk patented a leaky brain junction hypothesis/drugs which should reduce that, a few years ago - like you I was surprised. I assume that where you have developed a significant evidence base (doesn't apply here) then you can patent a discovery e.g. I think genes...

Thanks!

Government policy is supposed to be "evidence based"; the review panel will be required to operate on that basis. I'm not involved in health policy (I work at a junior level in planning policy - devolved UK administration); but it's really beyond a stretch to say that the (NICE) guidance, which...

The purpose on the review is guess what - to review the evidence. If there were well conducted reviews, e.g. with objective measures of improvement (activity monitors rather than questionnaires), then Per Fink should bring them to the review committee's attention. The second paragraph, you...

I think that, the standard Government line is that, all responses (to the consultation) are considered on there merits. E.g. Bupesh Prusty contribute to the NIH Conference a few years ago so "outside" input is fine. However, the "concept" is that if 1 million people support a crap idea and 1...

Yes Cort states "You have a vicious circle resulting in higher and higher cellular tryptophan levels." However, I assume that (to state that with confidence) you'd need to isolate all of the cell types, i.e. which rely on IDO1/2, and test them for tryptophan. Problem is there isn't a test e.g...

I wasn't sure if this was a realistic option to select participants for a ME study i.e. maximal (VO2). E.g. Cara Tomas, and others, published a study recently (small number of participants) and it would be interesting to see that replicated in a larger study. However, selecting participants on...

Thanks @Snow Leopard interesting i.e. "ventilatory threshold is it is the key measurement that is not affected by motivation" - I assume that there are issues with selecting participants (in studies) on this basis! @Michiel Tack

Yea, I was day dreaming about this; the bit where you have the amino acid sequence, for the virus spike protein, to identifying the genetic (RNA) code for that protein (the vaccine in essence) seems really quick - maybe two weeks? Since I don't know the underlying science I'm wowed by it e.g...

Is there evidence to support the "2.5% incidence"? It might be useful in lobbying @Michiel Tack

I recall an earlier paper by Baraniuk which suggested leaky blood brain barrier - I think Baraniuk took out a patient related to that. Still interesting though - if there's evidence. Is there a gut brain thing?

Is there anything which should jump out in a GWAS study (or anything which has turned up in a GWAS study) which would support this hypothesis? EDIT - @Simon M - a GWAS study might give us clues here i.e. to see if there is indeed a basis for this hypothesis. Was the "key physiological finding...

I think this is a thing of beauty (you've probably highlighted it before) CBT for IBS ---- you wouldn't make it up. Do you do a microbiome test before, and after, CBT i.e. as an objective measurement of improvement ---?

I wouldn't expect it to be mandatory - why? because the efficacy is high (possibly 95%) and people who are vulnerable, and get vaccinated, may not get life threatening illness (necessitating ICU) --- so I wouldn't see a case for mandatory vaccination. If efficacy was low; therefore R=1 (or...

Just Google "Radio 4 Schedule" - you can access them via this link as well*: Episode 3 How to Vaccinate the World Tim Harford reports on what we know and don't know about the Oxford/Astra Zeneca Covid 19 vaccine with a panel of experts. *https://www.bbc.co.uk/programmes/m000py6x

There's a BBC Radio 4 program "How to vaccinate the world" which might help to provide some insight - a lot of these questions can't be answered yet --- once you've vaccinated a few million people, and time has elapsed, then you'll presumably have evidence of whether boosters are required and...

More money for ME specialists; @Jonathan Edwards has highlighted how rheumatoid arthritis treatment was turned around by specialists. However, as Jonathan has indicated, I wouldn't get your hopes up about getting more resources (e.g. to fund specialists). I assume (haven't followed this or read...

Does anyone know when they are due to start requesting samples? OK it may be difficult to be definitive i.e. due the pandemic.

I recall hearing something about the discovery of a potential mechanism for the action of lithium in bipolar disorder. The suggestion was that lithium modifies the shape of a protein and that leads to an improvement in bipolar symptoms. Immunoregulatory drugs successfully treat autoimmune NMDA...