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Yea, from memory, @JaimeS ME Action said "psychological treatments don't work (i.e. to get people back to a normal life) so Governments shouldn't fund research into them ---". PACE was basically a waste of £5 million - that's UK tax payer money! @MSEsperanza

@Grigor I agree with what @Jonathan Edwards has written (above). I work at a very junior level in Government (UK devolved administration policy - planning policy i.e. not health). If I'm writing to the Minister re this issue then the first question is what is the problem? With PACE I guess...

Thank you very much for your reply.

I'd be very interested in @Jonathan Edwards take on this paper. I'm not clear why you would pursue autoantibodies as a cause of ME after rituximab failed; rituximab wipes out antibody/autoantibody producing B-cells. OK a small percentage of people could have an autoimmune form of ME and that...

Not sure what I'm trying to say here --- could be that a higher incidence of people with ornithine transporter gene variant confirms the switch in metabolism to using amino acids --- Chris Armstrong, Fluge and Mella --- have all suggested a switch to using amino acids for energy production.

Listened to the "Briefing Room" on BBC Radio 4 earlier and found myself thinking - fair dues to the Swedes --- you couldn't get ethical approval to do a "control group" experiment like that (open the schools -- see how many teachers and pupils get infected ---) i.e. do nothing and then the...

More brainstorming [I'm a member of this group https://europeanmecoalition.com/]: does this study show that questionnaires overestimated activity? does this mean that activity monitors would, in general, make it more difficult to (wrongly) argue that someone has recovered (post GET & CBT) and...

Thank you for your reply. Could you combine a physical stressor (I think this used tilt test) with a test of cognitive function? E.g. identify a group of people with ME using a physical stressor and then assess the cognitive performance (of the people with ME and the control group) before and...

I need to make an effort to even scan this paper. It seems they can separate people with ME, from healthy controls, i.e. based on activity levels. However, I wonder if it would be possible to do the same for cognition. Have any studies shown that it is possible to separate people with ME, from...

Yea this type of objective measurement would have shown that PACE was crap.

I guess that those applying for grants look at what the funding body funds/will not fund and then try to make their proposal fit. If the NIH rejected an application to investigate/develop the nano-needle then one thought is - couldn't the measurement be an artefact due to the fact that the cells...

Reminds me of what a former colleague said of a writer in residence at a local university i.e. "I though he was there to write about bright young up and coming researchers ----". Looks like this writer managed to write something based on pretty thin gruel --- mind you, I don't think they quite...

Haven't checked this but Phair is talking about intracellular tryptophan being elevated and the kynurinine pathway blocked. Is this paper measuring levels of Kynurinine in plasma and if so is there another source of Kynurinine? Also, some cells use IDO2 (potentially trapped) and some don't...

But it could be a double take i.e. the - "UK has done more than any country to emphasise what not to do" --- I'd add more than "any country in Europe" and a "?" --- Sweden's maybe a challanger after all

Worrying i.e. MUS - https://www.dvhn.nl/groningen/Als-de-dokter-niks-kan-vinden-25856002.html?fbclid=IwAR1f_ZSlA66ir-Q6BpGgZYj12PDwNlzO3wTT9slV8VEbM22MjpV3xmpWudA @Michiel Tack

Yes, I'd heard that excess deaths may be the best way to estimate the number of deaths due to coronavirus. In Germany they identified that, after the controlled the initial outbreak, the majority(?) of new cases were occurring in the health care system and then focused resources on that. So the...

Shouldn't try to respond to such a good analysis. If a very high proportion of UK cases were detected (by diagnostic test) then the % dying would presumably be much closer to that in Germany and other countries with developed health care systems. Suggests that we aren't testing enough people...

Someone like Peter Bottemly comes to mind.

Yea every country has it's myths. Coronavirus may result in the re-examination of some of those --- I've heard someone in the US saying that possibly it may mean the health system is changed - so that it's universally available I guess.

I think in Germany they test you before you go into hospital; haven't checked though. Maybe it's just admissions rather than appointments. Maybe the problem is it takes hours to do a test; not a terribly good reason for not testing though - more an argument for doing the testing as quickly as...