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    Open Pilot Study: A Novel Transcranial Magnetic Stimulation Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Maybe they saw that by a few minor changes in their procedures, they could qualify for ME research funding. That's likely to happen with other research projects: put out the sweet smell of money, and pesky bugs come around to feed... :mad:
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    A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID, 2021, Utrero-Rico et al

    I wonder whether long covid has the same 'treatments often work great the first few times, then stop working and never work again' syndrome.
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    Do meals affect heart rate and symptoms inpostural orthostatic tachycardia syndrome? 2021, Kate M Bourne et al

    I posted a link to a new finding on Phoenix Rising regarding another possible mechanism for ME affecting heart rate. They found glial cells in the heart, which are part of heart rate control. I believe that ME affects glial cells, so that could affect heart rate. Eating could alter immune...
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    Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Simonato et al

    I'm convinced that ME is neurological, so I don't expect serum studies to reveal much other than some downstream effects.
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    Insular cortex neurons encode and retrieve specific immune responses, 2021, Tamar Koren et al.

    This offers another possibility for chronic inflammation: those neurons might be maintaining the active state after the trigger has been removed. If you add in ME altering neural function, it could be locking us into a feedback loop, with the inflammation altering the neurons in a way that...
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    Acceptance and Commitment Therapy for ME/CFS - Discussion thread

    Is there any way we can convince psychologists to come up with ways to fix their own problems? They shouldn't give (bad) advice to other people until they fix their limited perspectives and poor experimentation procedures. :grumpy:
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    The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS

    I'm unconvinced that this hypothesis fits with the rapid switching between full ME symptoms and full temporary remission. This switch of state takes place over a scale of minutes rather than hours. I triggered remissions via three different chemicals: prednisone, cumin, and T2. I don't see...
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    Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue..., 2023, Guo,Lipkin et al

    I think if it was an effective treatment for ME, someone would have noticed it after taking butyrate supplements. I've had different antibiotics and drastic diet changes, which should have affected my butyrate production, but I didn't notice any significant differences in my ME.
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    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    I came across this news item just after reading this thread, and it seems to fit it: https://newatlas.com/health-wellbeing/microbiome-gut-bacteria-inflammation-colitis-pgp/ "But more recently P-gp has been found to also play a key anti-inflammatory role in the gut, producing molecules known as...
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    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    I'm sure my microbiome would be abnormal. There are so many foods and food families I need to avoid that my food diversity is greatly reduced. For many PWME, reduced activity levels might also affect the microbiome. Studies such as this really should use controls with similarly reduced...
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    Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in [SLE], 2021, Anderson et al

    If they're studying the neurological effects of QA, I don't think they should be using serum samples. Most QA in the brain is produced locally. The correlation they're probably measuring is from the disease affecting cognition via local QA production also affecting QA production elsewhere in...
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    Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of ME/CFS, 2021, Du Preez, Staines et al

    Seems like a good candidate for further investigation. My brief skim made it sound like magnesium supplementation should have an effect, but I haven't noticed any, but maybe it's not that simple.
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    Is ... COVID-19 causing an increased risk of psychological distress, psychotropic prescribing or sleep and fatigue problems? 2021, Abel, Chalder et al

    If the goal of a study is a desired outcome, for whatever benefits to the authors, it's all a matter of choosing experiments or carefully selected data that supports the outcome. A well designed study of something silly, such as whether slugs move more erratically during a full moon, is...
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    Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla, 2021, Godlewska et al

    I can't recall anyone claiming reduction in ME symptoms from taking lecithin (leads to myo-inositol ) oranges or cantaloupes. Oranges (a source of myo-inositol) were the initial immediate trigger of what became my ME, although that might not be related to myo-inositol (but can't rule that out).
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    Adverse event recording failed to reflect potential harms: review trial protocols psychosocial interventions, 2021, Papaioannou, Cooper et al

    Good. It seems pretty obvious that there's a need for that.
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    [Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome], 2021, Feng et al

    We can't even clinically verify ME in humans, and going by questioning humans (who can communicate in words) is fraught with difficulties, so any claims for rats with ME seems kind of meaningless.
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    The ‘medically unexplained symptoms’ syndrome concept and the cognitive-behavioural treatment model, 2021, Scott, Crawford, Geraghty and Marks

    Doesn't everyone suffer from post-exertion fatigue? I call it: "Getting tired". :) For ME, I prefer to use the term 'fatigue-like' instead of fatigue, which is a poorly defined term in any case. Are there any definite clinical measures of normal fatigue? For a normal, healthy person, does...
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    Patient perceptions of infectious illnesses preceding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Jason et al

    My ME also started with ‘I have felt that the flu is coming'. The muscle aches/body tenderness and overall malaise seemed identical to previous flu infections. However, the next day I felt fine again. Then a week later, the same feeling occurred, and this time I felt feverish and really...
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    Shared Individual Formulation Therapy (SIFT): an open-label trial of a new therapy accommodating patient heterogeneity in [FND], 2021, Gutkin et al

    The trick is in how you define 'works'. For psychology/psychiatry, you just choose some unquantifiable targets and choose your questions to give your desired results.
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    Patient perceptions of infectious illnesses preceding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Jason et al

    One problem is that if you want to find a cause of something and there's no way to prove or disprove the cause, it's fairly easy to find something to blame. I had a tetanus booster some months before I developed ME. Was that the cause? There's no way to test that. Did I sneeze at least once...
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