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    Number of musculoskeletal pain sites leads to increased long-term healthcare contacts and healthcare related costs, 2021, Mose et al

    When I saw the thread title, I checked to see whether they meant that the more pain relief web sites available, the more people would seek medical help for pain. The actual research finding was no less silly. :rolleyes:
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    Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation, 2021,Becattini et al

    I wonder whether this might provide some useful markers for ME.
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    Complement activation in a model of chronic fatigue syndrome, 2003, Sorensen et al

    I have a couple of type I allergies (Timothy grass pollen and what is probably fungal spores) but neither affects my ME symptoms. I think that for some people, type I allergic reactions might indirectly worsen ME symptoms, possibly through extra cytokines or depletion of resources or some such...
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    Will it ever be reasonably safe for PwME to go back into society, post-Covid?

    Alberta was quick to declare the emergency over and drop all restrictions. Now they're admitting that they were too optimistic, and the big surge in cases is filling the ICUs. I haven't noticeably changed my lifestyle due to Covid. I went to town only when I needed to before Covid, and still...
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    Asthenic disorders as a manifestation of chronic fatigue syndrome, 2021, Putilina

    I really don't consider 'aesthenic disorders' as being a superior term than 'central fatigue'. Central fatigue isn't well-defined, but at least it has some definition. How about we stop trying to rename things that we can't clearly define? If we manage to find a clinical cause of this...
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    Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Result in Sustained Improvement in ME/CFS - Pereira, Bateman et al, 2021

    While the trial doesn't seem to show strong evidence to support the claims for the drug, I haven't seen any dismissal of the hypothesis for the root cause of ME. The drug might fail to work as theorized for any number of reasons. I hope that someone follows up on the hypothesis itself. Maybe...
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    Fluctuating food sensitivities, theories?

    Niacin gave me suicidal thoughts, and hot flushes when I took an actual tablet of it. Maybe try a niacin tablet or some food rich in niacin and see whether that causes any of the symptoms. As others have said, changes to gut permeability or microbiome could explain the responses to various...
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    A comprehensive review of approaches to detect fatigue using machine learning techniques, 2021, Hooda

    Since yawns are contagious, does that mean that fatigue is? :yawn: I'm surprised that they didn't use muscle movements or posture as features. I'd expect frequency and speed of movements to decrease with fatigue. My question is: how did they determine the accuracy of their fatigue...
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes, 2021,Crewe et al

    Some people wonder why researchers haven't figured out the root cause of ME. Well, the body is immensely complex, with all sorts of subtle but important interactions. We read about these new discoveries, but how much is yet to be discovered?
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    Researchers in Sussex launch pioneering study looking into Long Covid

    The 'come up with therapies' part may be a wee bit optimistic, but we won't figure ME out without data, so the more projects collecting potentially useful data, the better. I believe that ME is primarily neurological (with downstream effects on the body), so I support studies of the brain.
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    "Tortured Phrases" plagerism in computer-generated translation in research articles.

    "Haze figuring" sounds like if fits ME. "My thoughts get lost in the haze." :unsure:
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    Exploring Symptom Fluctuations and Triggers in ME/CFS Using N-of-1 Observational Designs: Protocol for a Feasibility Study, 2021, McDonald et al

    Paid work for the researchers? It seems unlikely that it will benefit patients more than just telling them to pay attention to changes in symptoms and keep a food/activity/symptoms journal. We all differ too much in our symptoms and responses to factors for any general findings.
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    Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling, Bisht et al, 2021

    These specialized microglial cells might respond to the same triggers that regular ones do, so the neuroinflammation found in ME patients might involve these cells too, messing up blood flow.
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    PEM induced only by sensory/cognitive exertion - what does it indicate about the pathophysiology of ME?

    I got PEM from driving. The worse the driving conditions, the worse the PEM. Driving in the dark, in heavy snowfall, on icy roads, triggered severe PEM. The same drive during a sunny dry-road day usually didn't. I think it was the cerebral processing of inputs and the stress of the increased...
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    Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing, 2021, Maggini et al

    I tried CoQ10, with and without supplements, and with a reasonably healthy diet ... and didn't notice any effects. Even well-conducted trial results can be interpreted in ways that don't match reality very well.
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    Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with [ME/CFS], 2021, Baklund et al

    "You appear to be my healthiest patient."
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    CFS Model: ..idiopathic intracranial hypertension & spontaneous intracranial hypotension; caused by cranial venous outflow obstruction, 2021, Higgins

    I didn't bother to read the full paper, but the abstract sounds like they came up with a bunch of excuses for why a lack of evidence supporting the hypothesis shouldn't be considered as a lack of evidence.
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    Cognitive deficits in people who have recovered from COVID-19, 2021, Hampshire et al

    Wouldn't scoring on the test be affected by physical symptoms (concentrating less because you feel lousy) and changes in activities during the day (being less active due to feeling lousy) and changes in lifestyle (vegging out in front of TV rather than reading, crafting, etc)?
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    High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells, 2021, Hansen et al

    I did get worse symptoms from meat fats, which I thought was from palmitic acid (based on the responses to different foods). Carnitine blocked that. I wonder if it would affect their experiment cells too.
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    Hybrid immunity

    Yes, Moderna. I'm heading in for the shot today.
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