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    Hybrid immunity

    When I booked my second vaccine appointment, I was offered either a second dose of the Pfizer vaccine, or a dose of the other one (starts with an 'M'), which is supposed to be just as effective. I did ponder whether ME might cause problems with a different vaccine or with a second dose of the...
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    ..investigation of nutritional intake & supplement use in Australians with [ME/CFS] .. implications on health-related QOL, 2021, Weigel et al

    Desperation? No, the psychiatrists would probably come up with a fancier and even less meaningful term.
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    Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with [ME/CFS], 2021, Baklund et al

    It would be interesting to compare those with a modern sampling of typical underexercised poor diet subjects. :)
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    "Cooling Paper" technology

    Going by the photo, '10 degrees cooler' is due to being more reflective than wood that's painted red or green (fairly poor solar reflectivity). What I'd want to know is the temperature difference between his paper and white paint (regular or designed for solar reflectivity). My guess is that...
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    The Epidemiology of Insomnia and Sleep Duration Across Mental and Physical Health: The SHoT Study, 2021, Sivertsen et al

    So, did they come up with a clear, concise, quantifiable (and verifiable) definition of insomnia that everyone studying insomnia can agree to use?
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    Are there any good studies proving that food sensitivities are a real thing?

    I don't know of any actual studies, but I think it would be hard to prove that food sensitivities do not occur. Our bodies are amazingly complex in their biochemical interactions, so we all have different sensitivities to various chemicals. I was quite sensitive to nightshade toxins (potatoes...
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    Studies and data on Post-exertional malaise (PEM)

    The triggering and recovery of PEM would have different subsets, but the point is to discover the mechanism of PEM: whatever it is that changes as the result of triggering. That is likely to be the same for most PWME and maybe long-covid. Even if the reliable, consistent PEM subset was small...
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    Studies and data on Post-exertional malaise (PEM)

    Does anyone know whether long-covid PEM is consistent? Many PWME can reliably trigger PEM and have it show up a consistent x hrs after the exertion and have it last a consistent x hrs after it shows up. If so, then maybe we can get long-covid researchers, with their better funding, to do the...
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    Hypothesis: Altered tryptophan absorption and metabolism could underlie long-term symptoms in survivors of .. (COVID-19), 2021, Eroglu et al

    I do believe that my ME involves abnormalities in my kynurenine pathway. Too much QUIN would probably explain some (most) of my symptoms. I think niacin made me feel worse because without dietary intake of it, my enzymes would convert more of the excess QUIN into niacin.
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    Over which physiological abnormalities in ME/CFS is there a scientific consensus about?

    I'd rather see the research funding going towards figuring out what we all have in common, rather than studying downstream symptoms that only some PWME have. If resources were unlimited, sure, maybe it would lead to a treatment for a symptom faster than trying to find one that treats all ME...
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    Over which physiological abnormalities in ME/CFS is there a scientific consensus about?

    Even that is probably only 'a large subset of PWME' rather than something all PWME have. I didn't notice any reduction in my physical capabilities after significant exertion. I'm guessing that I wouldn't show a reduction on a properly done CPET test.
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    Media items about obesity

    Things found in old recipes, such as flours or grains or seeds. Over the years I've noticed several such things disappear from the shelves. It's not just foods. Ammonia used to be a common cleanser. I looked for some recently, and couldn't find any. Replaced by fancy brand-named cleansers.
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    Media items about obesity

    One thing I've noticed is that it's getting hard to find basic foods. On my last trip, I wanted to try some lamb, and the store only had one package of chops and two larger cuts. I used to see frozen legs cut into chops, but couldn't find those now. I guess the space has been given over to...
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    Media items about obesity

    My weight started to rise rapidly just before my ME developed (a link there?). My solution was to simply reduce my meal sizes. That worked really well, and I fairly quickly dropped back to my previous 'normal' weight, and continued to drop. I also learned that cutting too much fat from one's...
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    Media items about obesity

    I've heard a lot of Canadians returning from trips to the US say that they were amazed at the size of American meals; much larger portions than served in Canadian restaurants. What's the caloric difference between a typical French meal and a typical US one?
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    How effective are common medications: ... meta-analyses of major drugs, 2015, Leucht et al

    I had slightly reduced 'good' cholesteral, so my doctor recommended omega-3 supplements or statins. I did my own online research and found that statins weren't all that effective (and had worrisome side-effects) and that omega-3's lacked any reliable research findings that indicated more than a...
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    Post-Exertional Malaise ... Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in [CFS] Patients, 2021, Kujawski, Newton et al

    Hey, maybe they're all curry-loving people that cumin works for as a PEM blocker. :) As Invisible Woman says, it's a mess. It sounds like they did a poorly set up experiment and then tortured the results until it provided an interesting result.
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    Hypothesis The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review, Hanson et al (2021)

    To me, the lack of a definite 'all PWME have this virus' finding means that ME is not a viral disease. Viral infections might trigger ME in people susceptible to developing ME, and might increase the severity in PWME who are susceptible to that, but that there are also other PWME who triggered...
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    Designing a questionnaire on ME/CFS onset

    "specify time from onset to first ME/CFS formal medical diagnosis" It's been 20 years since my ME started, and I still don't have a formal medical diagnosis. There is no clinical test, so the best one could achieve is a doctor's 'professional opinion', and I haven't seen any point in bothering...
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    Article: Tissues, not blood, are where immune cells function

    I almost expect a paper to come out revealing yet another, separate, immune system in our bodies, that no one had noticed before. They keep finding new organs, new lymph channels and other new--and important--bits of our bodies, so maybe they'll discover that RBCs engulf pathogens, or that...
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