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It is interesting that Beentjes pulled out insulin resistance as going with ME/CFS. Maybe poor glycemic control is an aggravating factor if there is ME/CFS or LC present. I doubt that it is involved in the mechanism of the illness directly but things may turn out in an unexpected way.

Two phrases stood out for me: 'An important international scientific organisation' Sorry, not any more. 'Pockets of flourishing' That's S4ME that is - the real future.

The investigator is an author on this: Pharm Res. 2019 Oct:148:104450. Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities Gerwyn Morris 1, Basant K Puri 2, Adam J Walker 1, Michael Maes 1, Andre F Carvalho 3, Ken Walder 4...

As of 2025 I would say that any professional group, in the context of putting an opinion on the line, is just that.

Maybe it's a bit like the puma eyes motif decorating the porticos in Catholic Churches in Cajamarca (the place where Atahualpa was executed) in Northern Peru. The Cajamarcas never liked the Incas anyway and were happy to chant Catholic prayers as long as they could go on decorating their...

Human nature is complicated, Sasha.

I have come to think that physicians have always been witch-doctors at heart, over history. In the immediate post-war years of 1950-80 scientists became leaders within practical medicine, whereas a generation before the scientists with medical degrees mostly went into science. The payoff came...

Yes, it is certainly intriguing. And paradoxical effects might make a lot of sense if we are dealing with VH gene usage that functions normally as a sort of 'decoy'. Jo C and I had speculated about various predictions in the context of VH4-34 but it begins to look as if they might be relevant -...

As poisons tend to!

Well put.

This seems to be an obscure cell poison derived from sea-squirts. It might be useful in cancer. Not sure I would want to try it for Long Covid.

Actually this is quite clever way to do a valid control. You take a population and treat with X. You find those with highY all get better but those with lowY do not. That implies that getting better was due to X in the presence of a context marked by highY. The lowY's act like a placebo group...

Sorry, David, but this makes no sense at all. Surely we can do better than this. What about the problem that nearly all the services that are provided are incompetent or worse.

Everything is completely different over there. Medicine is a money-making business, full stop. Private physicians in the UK used to do the same but I suspect less keen on the litigation these days.

The text implies that they are. I am pretty sure that in the USA older people quite often get given a 'little bit of thyroxine' to pep them up on the grounds that even if the TSH is normal they might benefit. It is not so different from the European practice of giving a bit more than the TSH...

I know relatively little about RNA technology but amounts of RNA would not necessarily have anything to do with the clonal commitment to a particular VH gene rearrangement would they? A plasmablast in blood might presumably have a hundred times more RNA for that recombined Ig gene than a...

All a bit odd. In fibromyalgia people are supposed to be oversensitive to things like heat and pain.

This seem pretty irresponsible reporting. Thyroxine will lower bone density. We have known that for forty years. (I assume T3 will as well.) If you take more thyroid hormone than you need then your bone density is likely to be lower than it needs be. If you are hypothyroid you need to have...

"Many questions remain unanswered in this case. One of them concerns the validity of the diagnosis CFS/ME: Given its currently low validity, does it lead to its use as mimicry in the context of artificial disorders?" This seem very confused. In what sense is there 'currently low validity' I...

I would forget their opinions and attitudes and focus on the story. It is a story very similar to that given by members here who are confident in their own ME/CFS diagnosis.