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MAGENTA remains puzzling to me because the treatments are so much alike. It seems like one form of graded activity versus another that focuses on physical activity. So what exactly is being tested here: whether graded activity should focus on physical activity or not? They also say they used a...

So the recruitment rate (±50%) was higher than expected (±25-30%). The drop-outs were relatively low: 3 out of 40 (7,5%) in both the GET and activity management arm. The vast majority of patients (155/161) were recruited at centre one, which I assume is Bath. The recruitment site at...

in this preprint, researchers looked at antibody-dependent cell-mediated cytotoxicity (ADCC) which is related to NK cytotoxicity. They looked at families where more than one member had developed ME/CFS. They found that ME/CFS patients had lower ADCC than healthy controls, but the same was true...

I also got that impression. But there were much more datapoints for the ME/CFS group than the control group and all compressed on a small figure. So it could be that there's a bit of an optical misinterpretation where we underestimate the datapoints that are clustered togehter in the lower...

Could you change the title from Unutmaz et al. to Karhan et al.? One can always indicate who the foremost author is (the person that helps us to recognize the research team) in the post below but for titles, the first author is normally used and it can be confusing if you use another name...

Would you say your ME/CFS was rather unusual? Did you have a feeling that you had a typical of ME/CFS presentation or did you think you'd had a rather uncommon form of ME/CFS having those relapsing-remitting flu-like episodes?

That 's great news. Thanks for sharing this. It gives a bit of hope to the rest of us.

Thanks @Tom Kindlon and @Dolphin !

Got a PACE-trial question: in the statistical analysis plan (Walwyn et al., 2013) it is said: But has this data ever been reported in a paper? The main PACE trial paper in the Lancet reported only the expectations of trial participants, not of the staff. Does anyone have an overview of data...

I think they would argue that in the past conversion disorder described the same patient population but that this label had wild theoretical assumptions that are not supported by evidence. So, therefore, the term functional neurological disorder is preferred.

I see. I might have interpreted psychotherapy a bit differently, not psychoanalysis or correcting thought patterns, but having a psychologist who you can talk to, who supports you and might help in coping with a chronic illness etc. I suspect that might be helpful for some ME/CFS patients, even...

Here's my attempt to convince the devil's advocate. Because the research community in ME/CFS is so small, anyone stepping in will have a relatively larger influence than in other fields of medicine such as cancer or Alzheimer research. While in other fields a researcher will follow a...

Would it be possible to see what those applications were (like the title and author) cause that seems like the only way in figuring out what's happening. I sometimes wonder whether the following might have something to do with lower applications in recent years: the fact that ME/CFS is less...

What do you mean exactly?

In the video with Ben, Ronald Davis said that freezing samples weakens the electro-impedance signal. At minute 15.40:

Saugstad was one of the people who wrote to Godlee about the Lightning process trial. http://www.virology.ws/2019/09/03/trial-by-error-calls-for-retraction-of-the-lp-study/ From what I can find online, he seems like a respected figure who has published important work in neonatology. I found...

I disagree with some of the comments made here. I don't think the study is that bad and I don't think Klimas has to justify herself. The results aren't very surprising, perhaps rather obvious, but I prefer that researchers publish the data they have, especially if it's about a large group of...

Agree. Found a version of the depression subscale here. It seems like a highly problematic tool to detect depression in ME/CFS. It's rather frustrating that with so many researchers focused on the psychological aspects of ME/CFS none of them has taken the effort to develop a depression...

Weird journal. American Journal of Social Sciences and Humanities. Seems to have a rather broad scope and can't find an impact factor. Does anyone know if it is legit?

This is very disappointing. It seems that the sole ME/CFS research team in Poland is prescribing GET based on the deconditioning theory to all ME/CFS patients that come to their centre. And they do not seem to make an effort to obtain reliable data out of this. As has been noted by others...