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Abstract Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains...

Summary Background Children can develop Long Covid, however long term outcomes and their predictors are poorly described in these patients. The primary aim is to describe characteristics and predictors of Long Covid in children assessed in-clinics up to 36 months post-SARS-CoV-2 infection, as...

The technique could help researchers understand how diseases change the body LINK Achieving optical transparency in live animals with absorbing molecules, 2024, Zihao Ou et al LINK

Moved posts I was going to present this Lightning Talk at the Stanford ME/CFS research meeting tomorrow, but due to a last minute shake-up, I won't be able to. So I'll present it here. @RenegadeRes Credit to @tessfalor for slide template. 1/n

Abstract Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). MS patients have elevated titers of EBV-specific antibodies in serum and show signs of CNS damage only after EBV infection. Regarding CD8+ T-cells, an elevated but ineffective...

Influence of mRNA C-19 vaccine dosing interval on the risk of myocarditis, 2024 Abstract Myocarditis is the most salient serious adverse event following messenger RNA-based Covid-19 vaccines. The highest risk is observed after the second dose compared to the first, whereas the level of risk...

No way! Ugh ME/CFS is not 'mechanical'.

Highlights POTS causes cardiovascular instability and severe symptoms. Postural hyperventilation is thought to cause POTS, but the mechanisms are unclear. Reduced stroke volume and brain perfusion drive postural hyperventilation in POTS. Stroke volume and brain perfusion should be targeted as...

I'm sorry I must have missed something. Is there a study by Wust concerning M.E biopsy groups and PEM? I'm only aware of the study for LC.

I did a power walk 5 week post Covid infection after I felt recovered and woke up the next morning unable to stand or walk for 3.5 weeks. No negative effect on my cognitive functions. It was not delayed PEM as I experience with M.E. Same thing happened in 1992 post-infectious viral...

Question Are there associations between hormone therapy (HT), socioeconomic status (SES), and discrepancies between chronological and biological age among postmenopausal women, and can this explain the association between HT and risk of mortality? Findings In this cohort study involving...

Cardiac diastolic maladaptation is associated with the severity of exercise intolerance in SCA patients, 2024, Thomas d'Humieres et al Conclusion and perspectives This pilot study provides a new understanding of the mechanisms associated with exercise limitation in SCA patients, adding the...

Abstract A potential beneficial effect of hyperbaric oxygen therapy (HBOT) on complaints of long COVID was found, leading to increased demand for this treatment despite many remaining clinical questions and lack of formal guideline recommendations and reimbursement. A registry was set up in...

'General Hospital' Icon Emma Samms Talks Latest Return to the Show Amid Her Battle with LC Samms has had a rough few years, as she has been hit pretty hard with long COVID, and was unable to leave her hometown of London for outside work. “I’ve been like this now for four and a half years...

Merged thread Judge rules forklift truck driver's rare Long Covid symptom is a disability Mr Thompson was dismissed from his job in May 2023 and in July he was diagnosed as having a functional neurological disorder resulting from Long Covid. He then launched an employment tribunal claim for...

Abstract Background Long COVID is prevalent in the general population. Exercise is a promising component of rehabilitation for long COVID patients. Aim This study examined the effects of exercise interventions on managing long COVID symptoms. Methods In this systematic review and...

My understanding is that symptoms of exercise intolerance occur immediately after exercise?

If cells are less deformable, it reduces the ability to supply oxygen to tissues in the body. It doesn't effectively allow cells to perform their function to oxygenate tissues, cells needs to undergo significant deformation and be able to elastically recover to their original shapes. RBC...

Abstract Sickle cell disease (SCD) is characterized by central (cardiac) and peripheral vascular dysfunctions, significantly diminishing exercise capacity and quality of life. While central cardiopulmonary abnormalities in SCD are known to reduce exercise capacity and quality of life; the impact...

I have this too. I live in a high-rise and I pray the fire alarm doesn't go off when I'm feeling this way. The elevators shut off and I would have to take the stairs. Then I have periods when I can go power walking 2-3x/week. Who knows.