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Abstract Type I Interferons (IFN-I) are central to host protection against viral infections. While any cell can produce IFN-I, Plasmacytoid Dendritic Cells (pDCs) make greater quantities and more varieties of these cytokines than any other cell type. However, following an initial burst of IFN-I...

My 25 hydroxy test from 2006 was at 26 from taking 1000iu's daily. I checked over my results from 2007 from taking 3000iu's vitamin D for 6 months: Vitamin D (25HYDRO) - 144 (ref 25-200 NMOL/L) Vitamin D (1-25 DIHY) - 153 (ref 40-150 PMOL/L) Came with a 'warning'. These tests were taken after...

Merged threads Low ferritin levels for pwME has been a mystery. My levels were normal when I was tested by an Internist during the first year of illness, but rapidly started decreasing for no apparent reason for many years after. I took iron supplements regularly. No one could figure...

Interesting that an Emergency Medicine doctor is posting on Reddit for info on how to deal a 'difficult' LC patient. Receiving decent suggestions though and not 'it's all in their minds", unlike pwM.E.

Another thing is that you won't absorb vitamin D if your magnesium levels are low. So, how does magnesium affect vitamin D biology in the body? It is a cofactor in the synthesis of vitamin D from both exposure to sunlight and dietary sources. “Magnesium deficiency shuts down the vitamin D...

My vitamin D levels went over the ref range when I started taking 3000iu daily years ago. I take 2500's daily during the fall, winter and spring months but can't get tested anymore. I don't take any during the summer as I'm able to sit out and get sunshine.

Early on, I squeezed my way into the long COVID clinic at UHN, led by Dr. Angela Cheung. Just having some validation and a diagnosis was helpful. I learned that I had a combination of long COVID phenotypes, or groupings. The first is the brutal cocktail of severe fatigue, brain fog and...

There is also a problem if patients aren't getting their vitamin D levels tested before they start supplementing.

Merged thread Man dies from too much Vitamin D with highest possible levels in his body as officials issue warning The conclusion of the inquest was death by misadventure. Surrey Assistant Coroner Jonathan Stevens has since released an official statement claiming that the supplements...

I don't know if this means anything, but my alpha-ketoglutarate (urine) was at 1 (ref range 5-80) during 2 day post-exercise PEM.

Abstract Although orthostatic hypotension (OH) has long been recognized as a manifestation of autonomic dysfunction, a growing body of literature has identified OH as a common comorbidity of hypertension. This connection is complex, related to pathophysiology in blood pressure regulation and the...

Abstract Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance of bacteriuria after antibiotics. To elucidate the basis for these...

I wore a proper fitting quality N95 mask 2 1/2 weeks ago when I was out grocery shopping and caught a cold or possibly Covid. I developed a sore throat, coughing all night and mild muscle fatigue for one week. The maskless cashier was talking too much when I was only 3 ft away from her...

Background: The development of chimeric antigen receptor (CAR)-T cell therapy has revolutionized treatment outcomes in patients with lymphoid malignancies. However, several studies have reported a relatively high rate of infection in adult patients following CD19-targeting CAR T-cell therapy...

In North America, a campfire story is a form of oral storytelling performed around an open fire at night, typically in the wilderness, largely connected with the telling of stories having supernatural motifs or elements of urban legend.

She has deleted 'recovered from chronic fatigue syndrome' from her Instagram account but she continues to tell her campfire story on her website.

New study results challenge the idea that vaccine immunity fades quickly https://www.mountsinai.org/about/newsroom/2024/longterm-data-reveals-sarscov2-infection-and-vaccineinduced-antibody-responses-are-longlasting

My dear best friend died from complications of M.E after 18 years of severe illness but wasn't bedbound. He was able to drive to Costco and Home depot to buy garden supplies and shop a little. He was more mobile than I was and was able to leave the house at least twice a week. He was a...

Key points summary Recent thermodynamic modeling suggests that preserving the O2/CO2 ratio in brain tissue is critical for preserving the entropy change available from the oxidative metabolism of glucose and the phosphorylation potential underlying energy metabolism. The hypothesis tested is...

Abstract Purpose This multicenter, prospective study is designed to investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the Middle Ear Effusion (MEE) of patients developing Otitis Media with Effusion (OME) subsequent to an Omicron infection. The...