Search results

A post about a new report on Long Covid in Belgium - the report has an extensive scope including epidemiology and patient needs - here

This study thread is relevant to the discussion: Persistent clotting protein pathology in Long COVID/PASC is accompanied by increased levels of antiplasmin, 2021, Pretorius et al

A post about the Microclot hypothesis has been moved to The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS

I think Ken Lassesen might be making the mistake I made, of seeing 'hypoperfusion' referred to in this study and mixing it up with global hypoperfusion (that still might be a thing, but this paper is not evidence of it). The levels of 'hypoperfusion' in some regions of the ME/CFS brains that...

Could it be that someone in chronic pain and/or fatigue might adapt over time by down regulating the activity of the ACC? So, we might expect to see the same thing in people with rheumatoid arthritis, for example? Altered cerebral pain processing of noxious stimuli from inflamed joints in...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999014/ Arterial spin labeling in neuroimaging, 2010, Petcharunpaisan et al I found this paper by Petcharunpaisan et al useful in understanding the technique. Unlike techniques where a tracer is injected into the person, the imaging labels the...

That's a pretty important finding to support advocacy for ongoing research into Long Covid i.e. we know that vaccination doesn't entirely prevent breakthrough Covid-19 infections, and this study suggests breakthrough infections have about the same chance of causing Long Covid as Covid-19...

I thought it might be useful for us to get to grips with this issue. The GET defenders have said that NICE chose the trial endpoints it looked at incorrectly. As I understand it, NICE chose the longest followup points where possible, and in the case of PACE, that was 135 weeks. The GET...

I was wondering what a reduction in cerebral blood flow of the order talked about in this paper might mean. I found this paper: https://onlinelibrary.wiley.com/doi/10.1111/cns.12780 Advances in chronic cerebral circulation insufficiency So, this study reported cerebral brain flows in the...

The pages were discussed on this thread: Kings College London: Persistent Physical Symptoms Research and Treatment Unit Maybe someone who participated in that thread archived it.

@Woolie; @SNT Gatchaman - one for you

The ME/CFS subjects met all of the criteria you would want them to (CCC, ICC, IOM). The imaging found that there was hypoperfusion in the limbic system of the ME/CFS subjects. Cerebral perfusion in these brain regions was reduced by about 34% in comparison with the HC group. That seems quite...

This is my interpretation of that: Arterial spin-labelling (ASL) is a brain imaging technique; pseudo-continuous spin-labelling (PCASL) is a version of ASL that has some advantages e.g. whole brain coverage. A study using ASL in healthy controls found that they could predict levels of fatigue...

Xia Li 1 Per Julin 2 Tie-Qiang Li 1, 3,4 1 Institute of Information Engineering, China Jiliang University, 258 Xueyuan Street, Xiasha Higher Education Zone, Hangzhou 310018, China 2 Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, S-17177 Stockholm, Sweden 3...

I'm not sure how important the differences in abundances are - here are graphs from the paper for two key species. Green on the left is controls, red on the right is ME/CFS. There's a lot of overlap and the average isn't very different, even though the p value suggests a difference. Maybe...

I was just looking through the threads tagged with butyrate and noticed this interesting one posted by @alicec: Extensive impact of non-antibiotic drugs on human gut bacteria (2018) Maier et al They screened non-antibiotic drugs taken by humans against a range of bacterial species in the gut...

Clicking on the "butyrate" tab on the left under the title brings up some of the threads relevant to butyrate findings in a range of illnesses.

Just a reminder that this 'classic' video can be down voted if watched in Youtube.

I thought the people who worked to make the 2021 guideline happen and those worked to make it good might like to know: A link to the 2021 NICE ME/CFS Guideline will be added to the Resources sections in the online guidance documents about ME/CFS that we have for medical professionals (doctors...

These are the people on the editorial board of the IACFSME's journal 'Fatigue: Biomedicine, Health and Behavior'. Founder and Editor Fred Friedberg, Ph.D., Stony Brook University Medical Center, USA Associate Editor Yasuyoshi Watanabe , M.D., Ph.D., Osaka City University, Japan Editorial...