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  1. Jonathan Edwards

    Meaning of the word 'malaise' and its use in the term Post-exertional malaise (PEM)

    Arthralgia and myalgia are too specific. It isn't clear that the symptoms are coming from these structures. In polymyalgia rheumatic, for instance, the 'myalgia' is probably coming from perimysial fascia and ligament. Malaise is a more appropriate term for a more generalised sense of being...
  2. Jonathan Edwards

    “Dr. Ken Friedman and Dr. David Maughan – ME/CFS and Long Haul Covid Similarities and Ramifications” podcast

    That is pretty much what malaise means in medical terminology. It is what people with prostrating infective illness like typhoid have - very much involving joint and muscle pain. __________________ This post has been copied and following discussion moved to this thread: Meaning of the word...
  3. Jonathan Edwards

    Meaning of the word 'malaise' and its use in the term Post-exertional malaise (PEM)

    This post has been copied and following discussion moved from this thread: “Dr. Ken Friedman and Dr. David Maughan – ME/CFS and Long Haul Covid Similarities and Ramifications” podcast That is pretty much what malaise means in medical terminology. It is what people with prostrating infective...
  4. Jonathan Edwards

    Exercise Training in Post-COVID-19 Patients: The Need for a Multifactorial Protocol for a Multifactorial Pathophysiology, 2022, Cattadori et al

    Well I've been listening to you guys with ME for 8 years now and what I have had seems to have the same basic pattern. It is also reminiscent of what I had 50 years ago 6 months after EBV. As I indicated I don't think I have ME, but equally I do not have cardiac or lung disease. There is a...
  5. Jonathan Edwards

    Exercise Training in Post-COVID-19 Patients: The Need for a Multifactorial Protocol for a Multifactorial Pathophysiology, 2022, Cattadori et al

    But isn't it that as well? I am now three weeks from starting Covid-19 (second bout). I am probably 2 weeks from severe symptoms and a week from mild/moderate. There is no way that I would see any reason to undertake an exercise program. I have been doing odds and ends of things that I might...
  6. Jonathan Edwards

    Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic re..., 2022, Schmidt et al

    I have been through it. It is pretty much what it says on the tin - very few treatments come out with high quality evidence on Cochrane reviews and harms are under-reported and common. But the pinch of salt is that they think GRADE is great and maybe even a bit strict. On the other hand that...
  7. Jonathan Edwards

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Absolutely not, because the BPS people have no evidence to make such claims - (other than where the NICE guideline is in fact at fault that is.) If the idea is to pass on what the NICE guideline says verbatim then it should be presented like that - or just give the URL for the guideline. If the...
  8. Jonathan Edwards

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    In the abstract yes, but I don't buy this as an excuse. The NICE committee had an ethical duty to produce a guideline based on reliable evidence and good rational argument. They did pretty well but on this point they muffed it. To my mind anyone writing on a website that appears to be...
  9. Jonathan Edwards

    Magnesium

    But is that right? As far as I am aware clinical magnesium deficiency is largely limited to specific conditions where it will be expected - like severe renal disease or malabsorption. I don't see any reason to think PWME are likely to need to take magnesium. That looks highly implausible. The...
  10. Jonathan Edwards

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    I don't see it as a consequence. To repeat it as advice you have to think it merits repeating. Strain wasn't on the committee so I don't see that he is obliged to repeat it.
  11. Jonathan Edwards

    The Relationship between Physical Activity and Long COVID: A Cross-Sectional Study, 2022, Wright et al

    Not really. You wait until you are ready. Unless someone discovers how to get rid of LC symptoms, but that is another matter.
  12. Jonathan Edwards

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    So who produces and funds Medscape? We seem to live in a world of predigested information served up 'on message' in line with nobody quite knows who.
  13. Jonathan Edwards

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    I am wondering what 'Guidelines' is - who produces it and who funds it and what relation if any it has to NICE? I find this article quite disappointing because it seems to be a mish mash of repeated material from various sources rolled into a 'recipe' without any background thought. Why is CBT...
  14. Jonathan Edwards

    B12/Folic Acid and D3/K2 Supplementation

    If he had been ill and not eating much that might be relevant to a low folate level but I doubt it has anything to do with the Covid, or vice versa. We have just had our second Covid after three jabs and it is pretty draining - now nearly three weeks in. I don't think all the stuff about...
  15. Jonathan Edwards

    an ‘invisible’ illness that benefits from a relationship-based care approach – BJGP Life, 2022

    Ethnography is also a type of social research that involves examining the behaviour of the participants in a given social situation and understanding the group members' own interpretation of such behaviour.[3] That sounds like 'gossip' to me. So this is meta-gossip: gossip about gossip.
  16. Jonathan Edwards

    Covid-19 vaccines and vaccinations

    Believing that people have the symptoms they have is a completely different thing from accepting causal explanations based on individual cases that can never be proven. Coincidences occur all the time. The only way to establish that there is a causal link is to do large systematic studies...
  17. Jonathan Edwards

    Who is Simon Wessely?

    What with the ex-king of Spain and some of the Windsors, being royalty isn't necessarily something to be proud of these days!
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