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  1. Peter T

    Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: The al-Ándalus project, 2021, Estévez-López et al

    As always my heart sinks with lines like “It is widely acknowledged that … … …”, and these are the opening words of this abstract.
  2. Peter T

    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    Thinking in historical/evolutionary terms, I suspect in most periods of history or even in a different contemporary culture I would have died relatively early on in the course of my ME, if not already eaten by the wolves, not directly from the ME but from another infection taking advantage the...
  3. Peter T

    Orthostatic intolerance

    I retrospectively now believe I had OI issues long before I was consciously aware of them. I was not aware of any issues around being upright, though I was aware of being less confident in relation to balance, feeling less confident climbing or totally freezing when walking on a steel net over...
  4. Peter T

    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    This implies, if I am understanding correctly, that PEM is somehow a normal bodily mechanism for self protection, such as normal tiredness is a mechanism to promote sleep or blinking to protect the eyes. We would then presumably expect to see it in a number of different situations unconnected...
  5. Peter T

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Also partial knowledge, too many intoxicated scientists out there: “A little learning is a dangerous thing; drink deep, or taste not the Pierian spring: there shallow draughts intoxicate the brain, and drinking largely sobers us again.”
  6. Peter T

    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    Given our current definitions of ME are purely symptom based, if someone who has ME turns out to have a mitochondrial related pathology that surely does not necessarily supersede the previous ME diagnosis. Rather you could argue, if it turns out everyone with an operational ME diagnosis has the...
  7. Peter T

    Covid-19 vaccination experiences

    Had my booster on Wednesday this week: 1st vaccination AZ - three days of severe reaction like bad PEM including severe headache, eased off and back to normal over a couple of days. 2nd vaccination AZ - only one day of headache and sore arm. Seasonal flue jab about a month ago - not had one for...
  8. Peter T

    Article: The coming battles over long-haul COVID-19 and long-term disability

    It may be that the current pandemic will provide sufficient numbers of people in similar enough circumstances to make a class action (of the sort that American legal dramas portray, if such exist in the real world) possible. Though I feel a bit uneasy hoping that sufficient numbers of people...
  9. Peter T

    NEW POLL! Are these good ‘ME’ images for the media? (See explanatory post)

    The big problem is that even if each of us had the services of an understanding and skilled photographer for a week and our personal selections of their out put were pooled and voted on we would still struggle to get a set of photos that all agreed on. I suspect we would be very hard pushed to...
  10. Peter T

    Exercise plasma boosts memory and dampens brain inflammation via clusterin, 2021, Zurien De Miguel et al

    It is plausible that humans have evolved to function optimally at a certain level of physical activity, all other things being equal. But we can’t currently say that with certainty or say what level and forms of physical activity might be involved. In terms of human evolution do we even know...
  11. Peter T

    The maintained attention assessment in patients affected by [ME/CFS]: a reliable biomarker?, Murga et al, 2021

    One potential way is to seek to match the patient and normal groups on a factor that is presumed to relate to premorbid cognitive ability, such as level of education or previous work status. So you would seek to find a match pair for each patient to make up the control group, and you would...
  12. Peter T

    “There’s Nothing Wrong With You”: Pain-Related Stigma in Adolescents With Chronic Pain, 2021, Wakefield et al

    You are not trying hard enough with the circular logic. Stigma is the secondary gain. People looking down on you and not believing you means you are the centre of their attention, even if they avoid you and you never see them. This is the wonder of a BPS approach that enables you to...
  13. Peter T

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Although it is not just clinical experience, but rather the clinical experience of one’s preferred in group. The homeopath will believe in one set of clinical experience, as does the pharmacist in their set of clinical experience, as does the psychotherapist their preferred set of clinical...
  14. Peter T

    Protocol ReCOVer: A RCT testing the efficacy of CBT for preventing chronic post-infectious fatigue among patients diagnosed with COVID-19.

    Indeed I would have thought keeping an activity diary could be as likely or even more likely to cause changes in behaviour than a worn measuring device. Over time it is possible to forget you are wearing a device, but keeping a diary is by necessity always a conscious act.
  15. Peter T

    Mistaken Identity: Many Diagnoses are Frequently Misattributed to Lyme Disease, 2021, Kobayashi et al

    Am I being foolish, but surely by looking just at referrals for Lyme’s assessment it is inevitable that you will find more false positives than missed diagnoses, as people where a Lyme’s diagnosis has never been considered as a possibility are much less likely to be referred for Lyme’s...
  16. Peter T

    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Prof Garner tweets “Nice Guideline for CFS/ME derived from activism, not research-from a recovered patient. I have never seen such a corruption of the evidence-informed guideline process.” Though what follows is my attempt at teaching my grandmother to suck eggs, I think it is worth repeating...
  17. Peter T

    The illness-disease dichotomy and the biological-clinical splitting of medicine, Tesio and Buzzoni, 2021

    Wouldn’t the middle ground be a flattened ovoid, rather like a squashed deflated rugby ball?
  18. Peter T

    Open University of Oxford: CFS study: Researching the biochemistry of Chronic Fatigue Syndrome, closes 30th Dec 2022

    Given the use of the term CFS and the prominence of the idea of fatigue, one wonders if this will result in a preselection of very specific subjects, which along with the small sample size makes how they define ME/CFS and which diagnostic criteria they use very critical in ensuring a...
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