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"CFS was defined as ICD-9-CM 780.7 and ICD-10-CM G93.3, R53.8" so much broader than ME, this includes "malaise and fatigue" in general. Common issue with studies from Taiwan.

Seems like the big problem here is that they divided their data into 80% training / 20% test, but they divided data from cells (2155 cells from 98 patients and controls) rather than the people. So it doesn't seem surprising that their ML algorithm, which was essentially trained to distinguish...

They did find that 15% of the treatment group self identified as having LC versus 21% of the control group (p 0.06, so it wasn't significant at this sample size). That seems like a more useful measure than the "reporting any of this list of symptoms in an interview" approach. This also seems...

I think more research into post-chikungunya and post-dengue could be very valuable, because these have a clearly different presentation than typical ME that is more clearly linked to symptoms in the initial phase, i.e. the joint pain. Having that specific, localized symptom to grab onto might...

It seems like the term CFS has come to mean something completely different in Taiwan, as we've seen a lot of these studies. I guess there isn't really a great solution other than just ignoring any study related to CFS from Taiwan.

@Hutan, here's one that's less cut off:

I agree that there seem to be two stages. Many people report often fairly mild post-viral illness lasting on the order of six months. We don't have good data on this, but LC and mono, for example, suggest that recovering after months is more common than developing years-long ME. At this point, I...

Simarron recently found high serum BH4, so I wonder what the story is here. Are they talking about deficiency in some way that includes high serum levels?

Interesting, Relyvrio is a combination of 3g sodium phenylbutyrate and 1g TUDCA.

The WASF3 muscle data alone might not be that convincing, but coupled with the transgenic WASF3 mouse data showing significantly lower running distance compared to controls, plus lower OxPhos/glycosis, lower muscle glucose and higher blood lactate, it looks to me like they might be on to...

I agree that Dr. Moreau plays a little too fast and loose with the term PEM in regards to his massage cuff, but I'd also say that for most of his results, the before and after aren't really important at all (mostly it's the difference between the controls and the patients overall, not...

The bit about generally lower, and for some asymmetrical between left and right hemispheres, cerebral oxygen levels was quite interesting (though brief). There is a little more in the Q&A at the end as well. More evidence for a problem with oxygen delivery in some form, is what I take from that.

Also anecdotal, but I started taking antihistamines (an H1 and an H2 inhibitor), thinking it might help with some gut issues. It didn't help my gut, but it absolutely did improve my general capacity and increase my threshold for PEM — especially for mental concentration. I went from only being...

The full paper is now available. Interesting that the samples were actually from Cambridge Brain Bank. They say they found evidence of active HH6 infection in two of three patients (though they had fewer brain samples from the third patient and given how many other negative samples they had...

I think we've seen from the previous Al-Aly Veteran's Affairs studies that their data fails to capture a lot of Long Covid of the ME-type (as opposed to things like acute cardiovascular outcomes), but it's still pretty interesting to see a significant reduction in risk across a variety of...

Abstract: Long Covid -- the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC) -- affects millions of people around the world. Prevention of PASC is an urgent public health priority. In this work, we aimed to examine whether treatment with nirmatrelvir in the acute phase of...

Very little, a bit of a sore arm, maybe a few hours of feeling very slightly off.

I got Novavax as a fourth shot this summer, after the first three Moderna doses had unpleasant side effects that lasted at least a few days. Very few side effects for me with Novavax. But as you note, it's based on Wuhan spike, not BA.5 spike, so less protective. I was planning to get a bivalent...

After the last Al-Aly study, I'm not too inclined to take this one seriously. The patient group is quite unrepresentative (older, unvaccinated men with quite a few health problems, many ending up hospitalized), the method is weak (electronic health records aren't going to tell you much about...

Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...