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Not really sure, hard to understand their description of measuring cytotoxicity in the meta analysis. Why would you think that? I can see the possibility that with fewer NK cells, cytotoxicity of each one might be upregulated to compensate.

So this is about how many cytotoxic NK cells there are and the recent "Meta-analysis of Natural Killer (NK) cell cytotoxicity" was about average cytotoxicity of NK cells, right? Not necessarily related?

That's interesting. They all have a very similar environment, presumably including similar diet and exercise, in prison, so I wonder if it's due to environment before they entered or genetics. Edit: Oh I misread, the abstract isn't saying they have a higher incidence in prison than others, it's...

From discussion: In this study, we used untargeted LC-MS/MS plasma proteomics to investigate the sex-specific associations between plasma protein abundances and mental health indicator scores in adolescents. Overall, 37 proteins were significantly associated with the total SDQ score using the...

Plasma proteome demonstrates sex-specific associations with mental health risks in adolescents Alexey Afonin, Aino-Kaisa Piironen, Jordi Julvez, Irene van Kamp, Katja M Kanninen [Pre-print] Abstract Adolescence is a critical developmental period marked by significant physiological...

Oh, I looked up the instructions for SF-36 and question 2 about how your health today compares to a year ago isn't actually included in any of the composite scores. Table 2 shows how to add them together, and it's the only question missing. And I found a paper that says it's basically just used...

Thanks I didn't know what VM was. But weirdly, I think the correlation is the opposite. The higher the severity, the more movements. I think it's mainly because of the MASQ, which has a higher score so weighs more in the final score, and is more for cognitive dysfunction. I wasn't sure if...

Yeah I was really excited to learn the forum could do that! I have a ton of fun trying to treasure hunt in data. I'm not very good at it, but I can imagine the possibilities. Thanks, you're probably right. I'll look at that. Though I didn't really care about multiple test correction with this...

SF-36 seems like a better metric than fatigue for disability severity. Here's the SF-36. I might exclude this question and make a custom total since this seems irrelevant for the level of disability one is experiencing at the moment: And it looks like the "RN Polysymptom Index" has a bunch...

Just as a sanity check, since I'm noticing something counterintuitive. The worse the fatigue severity, the more Earnings from the EEFRT study. I pulled up the raw data, and looked at Earnings vs some of the scores of the MFI-20 or MASQ surveys. (They aren't summed together in the raw data...

Edit: See post #873 for the finished version of the spreadsheet. ------- I thought it could be useful to create a dataset showing how much every single test from the deep phenotyping study is correlated to ME/CFS severity. I combined all data files into one which yielded about 3000 tests...

Their newest press release has more focus on ME/CFS: Link

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing Daisi Zheng, Xiaolong Li, Qingmiao Zhu, Zhiyan Huang, Peicheng Wang, Ting Zhao [Provisionally accepted] Edit: Now...

From Bateman Horne Center: Groups and Dosage: Participants were divided into: Low-dose group (750 mg valacyclovir + celecoxib). High-dose group (1,500 mg valacyclovir + celecoxib). Placebo group. Results: The low-dose group showed meaningful fatigue reduction. he high-dose group...

That's pretty awesome.

Not speaking for Kitty, but I also get insomnia the night after a day of intense overexertion. Might take like 3-4 hours longer to fall asleep. This is before any real PEM. It just feels kind of like trying to sleep after drinking a coffee. I guess it's possible less or worse sleep can at least...

Not really much going on for ALT in the deep phenotyping study. There's one outlier with 548, so the second plot is just zoomed in to everyone else. No one else has abnormal values, and not much difference between groups except maybe 2 participants are a little higher and 1 is very high.

Edit: No need to read this post. Just me figuring out the data said cells/ul, but they meant cells/mL. Only leaving it up in case someone else is confused about the high numbers. ------------- Am I missing something? Supplementary file 15 (requires downloading and unzipping) has a section for...

Mine are normal too, except for one time ALT was randomly high at 92. My doc immediately retested and got 20. TIBC, AST were also higher than my normal values for this test. AST returned to normal as well for the followup, and she didn't retest TIBC.

The deep phenotyping study on B cells in CSF in ME/CFS vs HV: So only 2 out of 16 with ME/CFS had any antibody-secreting B cells. I looked at the data on mapmecfs. For "B cell subset - Antibody secreting cell (%)", none of the 20 HV have any, and for ME/CFS one has 4% and one has 10.5%. These...