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I think methodology was identical. They didn't retest old samples - they used old data: One of those listed studies was on ME/CFS, Lyme, and healthy controls, so if there is data on B cells that Hutan mentioned for HC, there should be data for ME/CFS as well to see how it compares to long...

Ah, I thought the thread's paper was showing that they pretty much only enter during the acute EBV infection and then stick around forever, because if new B cells are going in, there'd be many more antibodies to EBV in the CSF.

So it sounds like the problem in MS is mainly B cells in the brain, so do you know if there are promising methods to get them out? Can you maybe inject something into the brain that sticks to B cells and makes brain immune cells more likely to grab them? (I don't really know much about how the...

Is it just that the B cells that enter CSF upon EBV infection already produce antibodies to pathogens seen before the EBV infection?

I was having a tough time following what this says so I gave the abstract to an AI to put more simply: ----- Background: There's a known connection between Epstein-Barr virus (EBV) and multiple sclerosis (MS), but scientists don't fully understand how they're linked MS patients typically...

Nope, 2010. I was just digging into Chia's enterovirus persistence research and I was surprised this wasn't posted here.

It would be interesting. Would have to keep in mind differences between infections. As the book above discussed, exercise only worsens health in some infections. E.g. it seems to be the case in polio, but not TB. So just recruiting based on a "cold" may cause too much variance to be useful.

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder Yanfang Wang, Yanqing Xi, Zongqi Wang, Guojuan Li, Zhuoqun Hao, Jiahui Nie, Jinxiang Li, Yuting Tan, Xiaodong Hu, Genwei Wang, Sha Liu [Provisionally accepted] Abstract Abnormal cognitive...

Increased Rates of Infectious Diseases in Fibromyalgia Patients: A Population-Based Case-Control Study Michal Vinker-Shuster, Eli Magen, Ilan Green, Eugene Merzon, Avivit Golan-Cohen, Ariel Israel Introduction: Fibromyalgia (FM) patients are known to have medical comorbidities. This study...

This is interesting. No live virus has been found in tissue without spilling into blood? If the virus was in the brain, where SARS-CoV-2 is known to be able to replicate, I'd think it'd be less likely for this to occur, given the BBB.

I'd understand saying it's unlikely, but I don't see how you can be sure that viral persistence doesn't cause long COVID. We're continually seeing new evidence of SARS-CoV-2 antigen persistence as technology improves. How can you be sure, for example, that we won't eventually find something like...

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry Art Schuermans, Andreas Verstraete, Vilma Lammi, Tomoko Nakanishi, Maddalena Ardissino, Jef Van den Eynde, Benjamin B. Sun, Marios K. Georgakis, Beatriz Guillen-Guio, Louise V. Wain...

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence John Chia, Andrew Chia, Michael Voeller, Tonny Lee, Robert Chang Aims Enteroviruses are well-known causes of acute respiratory and/or gastrointestinal infections and...

Unfortunately, I didn't respond to rapamycin. I took 5 mg/week for 4 weeks. It's been 3 weeks since my last dose. I was planning to do 2 months, but I was worried it was making me worse. I was getting slightly worse but hard to say if rapamycin was the cause, as I've been declining for a...

I looked at the study to see what it says about this "mental stress" and it's just two people (participants 34 and 38) that took >250 mile drives during the preparalytic stage of polio. It's not totally clear, but it looks like one died, and it doesn't give details about the other. I think maybe...

I think researchers may consider this kind of testing to be unethical. I'm guessing because the tested hypothesis would include increased risk of death from infection, among other things. From the Friman study a few posts up: --- Basically, it seems like the most obvious hypothesis is ME/CFS...

Thanks, I'd never heard this. Found this BBC article from 2021: Motor neurone disease: Intense exercise increases risk, say scientists Here's the study, which appears to be specifically about ALS, a type of motor neuron disease: Physical exercise is a risk factor for amyotrophic lateral...

There are some researchers, like John Chia and Maureen Hanson, that think chronic enterovirus infection plays a role in ME/CFS, so research on poliovirus, an enterovirus, could be useful. Looking at the reference from the study above for exercise worsening polio. It's a book available to borrow...

Symptoms and Pathophysiology of Post-Acute Sequelae of SARS-CoV-2 (PASC): A Cohort Study Olivier Robineau, Sophie Hüe, Mathieu Surenaud, Cédric Lemogne, Céline Dorival, Emmanuel Wiernik, Sebastian Brami, Jerome Nicol, Xavier de Lamballerie, Hélène Blanché, Jean-François Deleuze, Céline Ribet...

Treatments for Long COVID autonomic dysfunction: a scoping review Jonathan R Treadwell, Jesse Wagner, James T Reston, Taylor Phillips, Allison Hedden-Gross, Kelley N Tipton Purpose For Long COVID autonomic dysfunction, we have summarized published evidence on treatment effectiveness, clinical...