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49 is this conference paper, but I don't think there's an abstract: Are Cortisol Levels Low in Chronic Fatigue Syndrome?: A Meta-analysis, 2002, Harvey et al

These 17 reviewed studies are actually split across tables 1, 2, and 3. I thought it was one big table. The tables are looking at different cortisol measurements: blood, saliva, and urine. And there are a few repeat studies between tables, so it's fewer than 17 unique studies. But here are those...

For the cited review, I didn't look too closely, but Table 1 has 17 studies. Out of these, 9 found lower cortisol in CFS, 7 found no difference, and 1 found higher cortisol.

Four references in this study about exercise worsening health during an acute sickness, three of which are in rats. Acute Infection: Metabolic Responses, Effects on Performance, Interaction with Exercise, and Myocarditis, Friman et Ilbäck, 1998 (thread)

My mind could have been playing tricks with remembering hearing that delay decreased as people got more severe. I'll keep an eye out, but maybe some of the severe members here can confirm or deny it happening to them.

I also had trouble finding such research, except in tuberculosis, when trying to determine if exercise can cause worsening during acute infections, sort of like PEM. This paper has some references that might support this though:

Announcement from OMF: The Heart of the Matter OMF has received funding to start an ME/CFS biomarker study, called BioQuest. The goal of BioQuest is to identify a biomarker for ME/CFS that can be evaluated through a blood test and differentiate it from similar conditions. The study team plans...

That's weird. It's not under Thread Tools?

There are a few mentions of immediate PEM in research as well, for example: Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome, 2023, Vøllestad et al What I remember about delay decreasing with increasing...

After some searching and some thought, I think it's very possible that when people say "immediate PEM", they're experiencing rapid fatigability, like @Peter Trewhitt said. I immediately get very tired after eating, but it only lasts a few hours so I wouldn't consider it PEM. I can see how if...

As far as I remember, it's just from what people have said on forums. I'll try to search to find these anecdotes. The way I understand "rolling PEM" is you're constantly overexerting, so even as the PEM from one activity ends, new PEM is beginning, and you're always in PEM. Again I'll have to...

I'd also like to hear from someone who understands this better than me, but from a quick skim figure 1D certainly looks interesting. Demographics

From what I hear, delay in PEM changes to nearly immediate when people are very severe. If this is actually the same phenomenon, then a process that only occurs consistently after over 24 hours wouldn't make sense.

Just in case it's relevant, I looked at the deep phenotyping study data and found that the neutrophil:lymphocyte ratio was pretty highly correlated to subjective brain fatigue. Less so to some neurocognitive tests, and I didn't test against anything else. But high innate, low adaptive.

Just anecdotally, I had ECT while in the midst of the worst of my cannabis-induced psychosis, depression, and anxiety (and ME/CFS now that I know what it is). It had zero effect on anything. What I did experience was waking up from anesthesia on the last session unable to move or (edit...

Maybe wouldn't be okay for everyone, but I didn't have a problem lying on my stomach either with my custom thing, which is like the size of two flat matchboxes side by side covered generously in sports bandages which flattens it out, or a Polar H10 HR monitor on my chest. Might require a soft...

The thing I was kind of thinking might be an example is hydrocortisone. I thought I remembered reading that it might help temporarily but generally can't be used long term because it causes worsening. But I haven't had the energy to see if I'm remembering right. And even if it's true, the...

My project to make my own sensor is taking quite a while because I'm so tired. I got to the point where the thing can constantly record its own orientation, but has no real enclosure or way to attach to the body, so I just wrapped a sports bandage around it on my torso and wore it for a couple...

Comparative Metabolomics of Four Fatigue Disorders: Chronic Fatigue Syndrome (CFS/ME), Long COVID, Fibromyalgia (FM), and Major Depressive Disorder (MDD) Heather G Kuruvilla, Colleen Weaver, Joshua Jones, Hunter Tenpas [Poster presentation at Scholars Symposium 2024] Fatigue is a common...

Can you give any specific examples of what they got wrong?