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@Woolie can you check if they controlled for any confounders, like socioeconomic status?

Even if you don't agree with calling it "internalizing symptoms", is it not interesting that blood lead levels correlate to "sudden changes in mood or feelings; feels or complains that no one loves him or her; feels worthless or inferior; is too fearful or anxious; and acts unhappy, sad, or...

There have been almost as many papers on long COVID (6,564) in 4 years as there were on CFS in the 33 years from 1987 to 2020 (7101). And as far as I know, it still took until 2024 to report that SARS-CoV-2 antisense RNA can persist long after infection in humans. And in the case of COVID they...

It looks like it correlates to less exercise too, though, which might be what this ME/CFS study is looking at depending on how well they controlled for activity. Influence of exercise on exhausted and senescent T cells: a systematic review, 2021, Rao et al

We know there aren't any treatments known to consistently improve ME/CFS symptoms. But are there drugs or other non-exertion interventions that fairly consistently worsen symptoms in anyone that tries them? Examples of these could be useful for understanding mechanisms.

Oral minocycline therapy as first-line treatment in patients with Myalgic encephalomyelitis and long COVID: A pilot study Kunihisa Miwa [In Press, Journal Pre-proof] Background Myalgic encephalomyelitis (ME) is associated with long COVID and also untoward sequelae after anti-coronavirus...

Contribution of childhood lead exposure to psychopathology in the US population over the past 75 years Michael J. McFarland, Aaron Reuben, Matt Hauer Background More than half of the current US population was exposed to adverse lead levels in childhood as a result of lead's past use in...

They studied respiratory failure, not really long COVID here, but there will be a study of the same medication, anakinra, for long COVID, based on what they learned from this study. Germany, Greece, Italy, Spain: Safety and Efficacy of Anakinra Treatment for Patients With Post Acute Covid...

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial (SAVE-MORE trial) Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of...

Safety and Efficacy of Anakinra Treatment for Patients With Post Acute Covid Syndrome (PRECISION) Description People with COVID-19 might have sustained post-infection sequelae, known as Post-Acute Covid Syndrome (PACS). A recent consensus definition by an international panel of 265 patients...

Main takeaways Armstrong's lab thinks there may be links between neuroinflammation, hormone production, and cerebral blood flow in ME/CFS, long COVID, and POTS, so they are measuring all of these in one study. They are looking at astroglia-based neuroinflammation, which has not yet been studied...

For what it's worth, this study compared to sedentary controls. Though I imagine even people who barely leave the house would probably be sitting up more than people with ME/CFS. And I can't find any specific details on activity levels. I think any markers found that differ from controls that...

I really enjoy taking notes on videos and summarizing, so here's for the above video: Main takeaways Ron Davis discusses a project at OMF focused on the study of neutrophils in ME/CFS. A researcher at OMF named Vanessa is helping design a system for efficient, accurate study of neutrophils...

I don't know if this is what you're looking for, but there is a case report of a fluroquinolone antibiotic inducing something that sounds like PEM:

2:04:32 Michael Peluso–LIINC Updates, Expansion of LIINC to ME/CFS, Targeting the SCV2 Resevoir in Long COVID Clinical Trial Main takeaways: Michael Peluso discusses LIINC, a program that is currently studying long COVID, especially in regards to viral persistence. They plan to expand to...

Good catch. I contacted the author who confirmed that the statement in the abstract is a typo. It should say "which did not reach the p < 0.05 level". He is going to contact the journal to correct it.

Criteria is 1988 Holmes. This paper is interesting because it looked at 10 people with ME/CFS whose illness was immediately preceded by an acute infectious mononucleosis (EBV) infection (CIM group), 10 whose did not (non-CIM), and 26 healthy controls. Both ME/CFS groups had higher antibody...

Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome T Sairenji, K Yamanishi, Y Tachibana, G Bertoni, T Kurata Abstract To test for an association between chronic fatigue syndrome (CFS) and infections with Epstein-Barr...

A USA long term disability lawyer who specializes in ME/CFS is answering questions on Reddit.